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T7783

Thonzonium bromide

Synonym(s):

Hexadecyl(2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl)dimethylammonium bromide

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About This Item

Linear Formula:
C32H55N4OBr
CAS Number:
553-08-2
Molecular Weight:
591.71
UNSPSC Code:
12161900
PubChem Substance ID:
24900475
EC Number:
209-032-1
MDL number:
MFCD00133855
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description

cationic

mol wt

591.71 g/mol

application(s)

sample preparation

SMILES string

Br.CCCCCCCCCCCCCCCC[N](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2

InChI

1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H

InChI key

PBWQBSCBSFJTLE-UHFFFAOYSA-N

Application

Thonzonium bromide may be use to inhibit vacuolar ATPases (V-ATPases) to induce and study the effects of cytosolic acidification. Thonzonium bromide is also used to further characterize V-ATPases. Thonzonium bromide is use as a potential pDNA particle condenser.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
061H0612

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Ryosuke Suzuki et al.
Biological & pharmaceutical bulletin, 31(6), 1237-1243 (2008-06-04)
Non-viral DNA vectors are promising gene delivery systems and a variety of non-viral DNA vectors have been developed to date. Recently, we developed a novel non-viral gene delivery system--multifunctional envelope-type nano device (MEND). The MEND system has high transfection activity
A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection.
Gao Y, Gu W, Chen L, Xu Z, Li Y.
J. Controlled Release, 118, 381-388 (2007)
Rebecca M Johnson et al.
Analytical biochemistry, 398(2), 203-211 (2009-12-19)
Fluorescence intensity of the pH-sensitive carboxyfluorescein derivative 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was monitored by high-throughput flow cytometry in living yeast cells. We measured fluorescence intensity of BCECF trapped in yeast vacuoles, acidic compartments equivalent to lysosomes where vacuolar proton-translocating ATPases (V-ATPases) are
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