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Merck
CN

T8067

T-0156

Synonym(s):

2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C31H29N5O7 · HCl
Molecular Weight:
620.05
UNSPSC Code:
41106305
PubChem Substance ID:
24278761
MDL number:
MFCD03453030

Key Documents

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SMILES string

Cl[H].COC(=O)C1=C(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3C(=O)N1Cc5ccnc(C)c5

color

white

solubility

DMSO: soluble, H2O: insoluble, methanol: soluble

storage temp.

2-8°C

Gene Information

human ... PDE5A(8654)

Application

T-0156 has been used to study the intracellular mobilization of calcium in HEK293 cells that transiently coexpressed either rat or human GPR35 and Gqi5.

Biochem/physiol Actions

Potent phosphodiesterase V (PDE5) inhibitor.
T-0156 can also inhibit PDE6.

Preparation Note

T-0156 is soluble in DMSO (17.3 mg/ml) and methanol. However, it is insoluble in water.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
011K4702

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Yasuhito Taniguchi et al.
FEBS letters, 580(21), 5003-5008 (2006-08-29)
We found that zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, acted as an agonist for a G protein-coupled receptor, GPR35. In our intracellular calcium mobilization assay, zaprinast activated rat GPR35 strongly (geometric mean EC(50) value of 16nM), whereas it

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