T8451
Monoclonal Anti-Tau, First N-terminal Insert antibody produced in mouse
clone DC 39N1, purified immunoglobulin, buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
DC 39N1, monoclonal
form
buffered aqueous solution
mol wt
antigen 45-68 kDa
species reactivity
human
technique(s)
immunohistochemistry: 1:1,000
indirect ELISA: 1:2,000
western blot: 1:2,000
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... MAPT(4137)
Immunogen
first tau insert (N1).
Physical form
Solution in serum-free DMEM (without sodium pyruvate and sodium bicarbonate) containing 0.1% thimerosal as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
STOT RE 2
Target Organs
Kidney
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Novel Anti-tau Monoclonal antibody With Specificity for NI Terminal Insert.
Mikulova K, et al.,
Neurobiology of Aging, 25, S432-S434 (2004)
Giuseppina Amadoro et al.
Journal of Alzheimer's disease : JAD, 21(2), 445-470 (2010-06-24)
Synapses are ultrastructural sites for memory storage in brain, and synaptic damage is the best pathologic correlate of cognitive decline in Alzheimer's disease (AD). Post-translational hyperphosphorylation, enzyme-mediated truncation, conformational modifications, and aggregation of tau protein into neurofibrillary tangles (NFTs) are
Veronica Corsetti et al.
Brain communications, 2(1), fcaa039-fcaa039 (2020-09-22)
Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer's disease. We have explored whether passive immunization with the 12A12
Valentina Latina et al.
Acta neuropathologica communications, 9(1), 38-38 (2021-03-23)
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer's Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of synapses
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