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Merck
CN

T8451

Monoclonal Anti-Tau, First N-terminal Insert antibody produced in mouse

clone DC 39N1, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD04040609

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DC 39N1, monoclonal

form

buffered aqueous solution

mol wt

antigen 45-68 kDa

species reactivity

human

technique(s)

immunohistochemistry: 1:1,000, indirect ELISA: 1:2,000, western blot: 1:2,000

isotype

IgG1

UniProt accession no.

P10636

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

Immunogen

first tau insert (N1).

Physical form

Solution in serum-free DMEM (without sodium pyruvate and sodium bicarbonate) containing 0.1% thimerosal as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H373

Hazard Classifications

STOT RE 2

target_organs

Kidney

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
081M1582
041M1596
011M1221
110M1713
126K1028

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Novel Anti-tau Monoclonal antibody With Specificity for NI Terminal Insert.
Mikulova K, et al.,
Neurobiology of Aging, 25, S432-S434 (2004)
Giuseppina Amadoro et al.
Journal of Alzheimer's disease : JAD, 21(2), 445-470 (2010-06-24)
Synapses are ultrastructural sites for memory storage in brain, and synaptic damage is the best pathologic correlate of cognitive decline in Alzheimer's disease (AD). Post-translational hyperphosphorylation, enzyme-mediated truncation, conformational modifications, and aggregation of tau protein into neurofibrillary tangles (NFTs) are
Veronica Corsetti et al.
Brain communications, 2(1), fcaa039-fcaa039 (2020-09-22)
Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer's disease. We have explored whether passive immunization with the 12A12
Valentina Latina et al.
Acta neuropathologica communications, 9(1), 38-38 (2021-03-23)
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer's Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of synapses

Related Content

Data Sheet - T8451

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