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Merck
CN

T8524

Trizma® base

≥99.9%

Synonym(s):

2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Tris(hydroxymethyl)aminomethane, Trometamol

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About This Item

Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
EC Number:
201-064-4
UNSPSC Code:
12161700
MDL number:
MFCD00004679
Beilstein/REAXYS Number:
741883

Key Documents

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InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

SMILES string

NC(CO)(CO)CO

grade

Molecular Biology

description

aminopeptidase substrate

assay

≥99.9%

useful pH range

7-9

bp

219-220 °C/10 mmHg (lit.)

mp

167-172 °C (lit.)

foreign activity

DNase, RNase, protease, none detected

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Other Notes

The pH values of all buffers are temperature- and concentration-dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.
For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
128H5450
085H5734
085H5732
085H5731
085H5717

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Gayathri Kanika et al.
Journal of biochemical and molecular toxicology, 29(8), 349-359 (2015-03-17)
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine

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