T8900
Thiacetazone
Synonym(s):
4′-Formylacetanilide thiosemicarbazone
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About This Item
Empirical Formula (Hill Notation):
C10H12N4OS
CAS Number:
Molecular Weight:
236.29
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
203-170-6
MDL number:
SMILES string
[H]\C(=N/NC(N)=S)c1ccc(NC(C)=O)cc1
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Geoffrey D Coxon et al.
PloS one, 8(1), e53162-e53162 (2013-01-10)
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis. Thiacetazone (TAC) is an anti-tubercular drug that
Farhad Mostafavi Shahab et al.
Archives of pharmacal research, 32(10), 1453-1460 (2009-11-10)
KBF-611 is a new thiosemicarbazone derivative which has demonstrated significant antituberculosis effect. A sensitive and specific HPLC method was established and validated for the determination of KBF-611 and its deacetylated metabolite (KM) in mouse and rabbit plasma. Chromatographic separation was
Masako Wada et al.
Kekkaku : [Tuberculosis], 82(1), 33-37 (2007-02-22)
A 30 years-old-male was referred to our hospital for surgical treatment of multidrug-resistant tuberculosis in April 1998, three years after diagnosis of tuberculosis. All first-line anti-tuberculosis drugs and second-line anti-tuberculosis drugs were resistant on drug susceptibility tests by Ogawa medium.