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Merck
CN

T8947

Tissue Inhibitor of Metalloproteinase-1

buffered aqueous solution, suitable for immunoblotting and ELISA

Synonym(s):

TIMP-1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00285922

Key Documents

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Product Name

Tissue Inhibitor of Metalloproteinase-1 human, recombinant, expressed in CHO cells, ~500 μg/mL protein, buffered aqueous solution

Quality Level

200

biological source

human

recombinant

expressed in CHO cells

form

buffered aqueous solution

mol wt

~29 kDa

concentration

~500 μg/mL protein

technique(s)

ELISA: suitable, immunoblotting: suitable

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

Plays a key role in maintaining the balance between extracellular matrix (ECM) deposition and degradation, and can inhibit angiogenesis, a crucial step in tumor invasion. TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.
TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.

Physical form

Supplied in 0.01 M sodium phosphate buffer pH 7.3, 0.15 M NaCl.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
061M1613
061M1612
061M1611
061M1610
061M1609

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Gary J Litherland et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(8), 2175-2187 (2014-04-24)
To assess the role of glycogen synthase kinase 3 (GSK-3) as a regulator of cartilage destruction in human tissue and a murine model of osteoarthritis (OA). Surgical destabilization of the medial meniscus (DMM) was performed to induce experimental murine OA
Jiayin Peng et al.
Theriogenology, 84(9), 1636-1643 (2015-10-06)
Tissue inhibitors of metalloproteinases (TIMPs) are associated with several reproductive processes, such as mammalian follicular growth, ovulation, CL formation, and embryonic development. However, the expression and function of TIMPs in goat oviducts remain unclear. This work aimed to identify TIMP1
Lena Vinther et al.
Protein expression and purification, 101, 157-164 (2014-07-08)
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is an endogenous inhibitor of matrix metalloproteinases (MMPs) with reported tumor promoting, as well as inhibitory, effects. These paradoxical properties are presumably mediated by different biological functions, MMP-dependent as well as -independent, and probably related
Chung-Han Tsai et al.
Nature communications, 5, 4804-4804 (2014-09-04)
Rab small GTPases are master regulators of membrane trafficking and guide vesicle targeting. Recent publications show that Rab-controlled trafficking pathways are altered during tumorigenesis. However, whether any of the Rabs plays a metastasis suppressor role is least explored. Here we
Ming-Ta Sung et al.
Oncology reports, 34(1), 439-446 (2015-05-09)
Krüppel-like factor 4 (KLF4) plays important roles in development, stemness and tumorigenesis; however limited information is available on the detailed function of KLF4 in hepatocellular carcinoma (HCC). The objective of the present study was to examine the functional roles of
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