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Merck
CN

T9146

Thyrotropin releasing hormone

powder, γ-irradiated, suitable for cell culture

Synonym(s):

L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide

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About This Item

Empirical Formula (Hill Notation):
C16H22N6O4
CAS Number:
24305-27-9
Molecular Weight:
362.38
EC Number:
246-143-4
UNSPSC Code:
12352200
PubChem Substance ID:
329826900
Beilstein/REAXYS Number:
770238
MDL number:
MFCD00038640

Key Documents

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InChI key

XNSAINXGIQZQOO-SRVKXCTJSA-N

InChI

1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1

SMILES string

NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3

sterility

γ-irradiated

form

powder

potency

0.3-10 ng/mL

technique(s)

cell culture | mammalian: suitable

solubility

cell culture medium: 50 mL/vial

storage temp.

−20°C

Gene Information

human ... TRH(7200), TRHR(7201)

Biochem/physiol Actions

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
085K8906
062K8932
051K8944
010K8939

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Silvia Vidali et al.
The Journal of investigative dermatology, 134(1), 33-42 (2013-08-21)
Thyroid hormones regulate mitochondrial function. As other hypothalamic-pituitary-thyroid (HPT) axis hormones, i.e., thyrotropin-releasing hormone (TRH) and thyrotropin (TSH), are expressed in human hair follicles (HFs) and regulate mitochondrial function in human epidermis, we investigated in organ-cultured human scalp HFs whether
Joanna M Hawryluk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(47), 16943-16952 (2012-11-24)
Chemosensitive neurons in the retrotrapezoid nucleus (RTN) regulate breathing in response to CO(2)/H(+) changes. Their activity is also sensitive to neuromodulatory inputs from multiple respiratory centers, and thus they serve as a key nexus of respiratory control. However, molecular mechanisms
Bashair M Mussa et al.
Experimental physiology, 98(1), 25-37 (2012-06-05)
Recent investigation of the factors and pathways that are involved in regulation of pancreatic secretory function (PSF) has led to development of a pancreatic vagovagal reflex model. This model consists of three elements, including pancreatic vagal afferents, the dorsal motor
David M Thal et al.
ACS chemical biology, 7(11), 1830-1839 (2012-08-14)
G protein-coupled receptor kinase 2 (GRK2) is a well-established therapeutic target for the treatment of heart failure. Herein we identify the selective serotonin reuptake inhibitor (SSRI) paroxetine as a selective inhibitor of GRK2 activity both in vitro and in living
J Kamath et al.
Pharmacology & therapeutics, 121(1), 20-28 (2008-11-13)
Decades of research have established that the biological functions of thyrotropin-releasing hormone (TRH) extend far beyond its role as a regulator of the hypothalamic-pituitary-thyroid axis. Gary et al. [Gary, K.A., Sevarino, K.A., Yarbrough, G.G., Prange, A.J. Jr., Winokur, A. (2003).
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