T9444
TECK from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonym(s):
Thymus-expressed chemokine
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About This Item
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
16-17 kDa by SDS-PAGE (doublet), predicted mol wt ~14 kDa
Impurities:
endotoxin, tested
biological source
mouse
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.66 μg/mL
mol wt
16-17 kDa by SDS-PAGE (doublet), predicted mol wt ~14 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl25(20300)
Application
The interaction of TECK and its receptor CCR9 plays a pivotal role in recruiting the developing thymocytes to their distinct compartment of the thymus.
Biochem/physiol Actions
TECK, a CC chemokine, is chemotactic for activated macrophages, dendritic cells, and thymocytes.
Thymus-expressed chemokine (TECK) belongs to CC chemokine and is expressed mainly in thymus and small intestine. It can facilitate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. Further, TECK potentially assists in T Cell Development.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing at least 50 μg bovine serum albumin per 1 μg of cytokine.
Analysis Note
The biological activity is measured by its ability to chemoattract hCCR9 transfected BaF/3 cells.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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B A Zabel et al.
The Journal of experimental medicine, 190(9), 1241-1256 (1999-11-02)
TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on
A P Vicari et al.
Immunity, 7(2), 291-301 (1997-08-01)
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was
M A Wurbel et al.
European journal of immunology, 30(1), 262-271 (1999-12-22)
Chemokines are key regulators of migration in lymphoid tissues. In the thymus, maturing thymocytes move from the outer capsule to the inner medulla and thereby interact with different types of stromal cells that control their maturation and selection. In the
Siying Zhu et al.
PloS one, 9(6), e100167-e100167 (2014-06-18)
Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural killer cells and T cells. These cells might have an important role in the pathogenesis of ulcerative colitis (UC). The interaction of chemokine ligand 25 (CCL25)
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