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Merck
CN

T9694

Sigma-Aldrich

TARC from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

Thymus and activation-regulated chemokine

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About This Item

MDL number:
MFCD01868627
UNSPSC Code:
51111800

Key Documents

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biological source

mouse

recombinant

expressed in E. coli

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

2-10 ng/mL ED50 (Ability to induce chemotaxis of human CEM NKR cells)
2-8 ng/mL ED50 (for its ability to chemoattract mouse BaF/3 cells transfected with human CCR4 )

mol wt

predicted mol wt ~7.9 kDa

impurities

endotoxin, tested

UniProt accession no.

Q92583

storage temp.

−20°C

Gene Information

mouse ... Ccl17(20295)

Application

Mouse TARC (thymus and activation regulated chemokine) is a ligand for CC chemokine receptor 4 and is a potent and selective chemoattractant to helper T cells leading to their migration through the early phase of the immune response.

Biochem/physiol Actions

A CC chemokine; ligand for CCR-4; selectively expressed on T cells; chemotactic for T cell lines.
TARC is a CC chemokine that mediates the hippocampal-neuron survival in the CNS. It also enhances the CTACK-inducing effect of TNF-α in keratinocytes. Additionally, chemokines can modify trafficking (chemotaxis) of leukocytes, especially systemic T cells.
TARC, a CC chemokine and the ligand for CCR-4, is a receptor that is selectively expressed on T cells and chemotactic for T cell lines.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to induce chemotaxis of human CEM NKR cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
075K1602
081K0030

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I Lieberam et al.
European journal of immunology, 29(9), 2684-2694 (1999-10-03)
To investigate specific properties of dendritic cells (DC) which are not shared by other antigen-presenting cells, we compared gene expression patterns of mouse DC and macrophages by differential mRNA display. One of the cDNA identified coded for a murine homolog
Y Chvatchko et al.
The Journal of experimental medicine, 191(10), 1755-1764 (2000-05-17)
CC chemokine receptor (CCR)4, a high affinity receptor for the CC chemokines thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC), is expressed in the thymus and spleen, and also by peripheral blood T cells, macrophages, platelets, and basophils. Recent
Christian Vestergaard et al.
Experimental dermatology, 13(9), 551-557 (2004-09-01)
Thymus- and activation-regulated chemokine (TARC)/CCL17 and cutaneous T cell-attracting chemokine (CTACK)/CCL27 are both pivotal mediators of the inflammatory reaction of atopic dermatitis (AD). TARC attracts CCR4 positive T cells known to be mainly of Th2 subtype whereas CTACK attracts skin-homing
T Imai et al.
The Journal of biological chemistry, 272(23), 15036-15042 (1997-06-06)
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors

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