T9700
Monoclonal Anti-TWEAK Receptor/Fn-14 antibody produced in mouse
~2 mg/mL, clone TR-22, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-TNF-like Weak Inducer of Apoptosis Receptor
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TR-22, monoclonal
form
buffered aqueous solution
mol wt
antigen ~14 kDa
species reactivity
human
concentration
~2 mg/mL
technique(s)
flow cytometry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using HEK-293 overexpressing TWEAKR cells lysate
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TNFRSF12A(51330)
General description
Monoclonal Anti-TWEAK Receptor (mouse IgG1 isotype) is derived from the TR-22 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with human TWEAK receptor. Tumor necrosis factor receptor superfamily member 12A or TNF-like weak inducer of apoptosis Receptor (TWEAKR) or fibroblast growth factor-inducible immediate-early response protein 14 (fn14) is a type I transmembrane receptor comprising transmembrane domain, amino-terminal signal peptide, and carboxy-terminal cytoplasmic domain. The TWEAKR gene is mapped to human chromosome 16p13.3. TWEAKR is expressed in the placenta, lungs, kidney, and heart.
Immunogen
synthetic peptide corresponding to amino acids 39-52 in the N-terminus of human TWEAK receptor.
Application
Monoclonal Anti-TWEAK Receptor/Fn-14 antibody produced in mouse is suitable for:
- enzyme-linked immunosorbent assay (ELISA)
- immunoblotting
- flow cytometry
Biochem/physiol Actions
Fn14 induces growth effects in neurons independent of the ligand, TWEAK.
Monoclonal Anti-TWEAK receptor recognizes human TWEAK receptor
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in “frost-free” freezers is also not recom-mended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Katsuhisa Tanabe et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(29), 9675-9686 (2003-10-24)
For successful nerve regeneration, a coordinated shift in gene expression pattern must occur in axotomized neurons. To identify genes participating in axonal regeneration, we characterized mRNA expression profiles in dorsal root ganglia (DRG) before and after sciatic nerve transection. Dozens
Steven R Wiley et al.
Cytokine & growth factor reviews, 14(3-4), 241-249 (2003-06-06)
The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was initially described as a member of the tumor necrosis factor (TNF) superfamily in 1997. TWEAK is a cell surface-associated type II transmembrane protein, but a smaller, biologically active form
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