U0633
Urokinase from human urine
lyophilized powder, ≥500 units/mg protein
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About This Item
CAS Number:
UNSPSC Code:
12352204
eCl@ss:
32160410
EC Number:
232-917-9
NACRES:
NA.54
MDL number:
form
lyophilized powder
Quality Level
specific activity
≥500 units/mg protein
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PLAU(5328)
General description
High molecular weight form migrating at 54 kDa by SDS-PAGE under non-reducing conditions
Biochem/physiol Actions
Urokinase expression and invasiveness suppression by urinary trypsin inhibitor acts through MEK/ERK/c-Jun-dependent signaling pathways.
Physical form
Lyophilized from 1 mL of 50 mM Tris-HCl, pH 7.4 with 100 mM NaCl, 0.1% PEG 6000, and 200 mM mannitol
Other Notes
One unit will activate that amount of plasminogen which will produce a ΔA275 of 1.0 per ml per minute at pH 7.5 at 37 °C, when measuring perchloric acid soluble products from α-casein (1 cm light path).
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Jordan R Yaron et al.
Methods in molecular biology (Clifton, N.J.), 2225, 107-123 (2020-10-28)
Viruses have devised highly effective approaches that modulate the host immune response, blocking immune responses that are designed to eradicate viral infections. Over millions of years of evolution, virus-derived immune-modulating proteins have become extraordinarily potent, in some cases working at
H Kobayashi et al.
The Journal of biological chemistry, 276(3), 2015-2022 (2000-10-26)
Urinary trypsin inhibitor (UTI), a Kunitz-type protease inhibitor, interacts with cells as a negative modulator of the invasive cells. Human ovarian cancer cell line, HRA, was treated with phorbol ester (PMA) to evaluate the effect on expression of urokinase-type plasminogen
Xiaojian Tang et al.
International journal of biological sciences, 9(1), 55-66 (2013-01-05)
Gastric cancer (GC) remains a leading cause of death worldwide, and an elevated expression of osteopontin (OPN) may correlate with its poor survival. Alternative splicing of OPN can result in three isoforms, OPN-a, OPN-b and OPN-c. The aim of our
A Santillo et al.
Journal of dairy science, 105(11), 8609-8620 (2022-09-30)
The aim of the present study was to assess the dietary supplementation of tannins to grazing dairy cows in 2 seasons characterized by a good quality pasture (spring) or a poor-quality pasture (summer). The effects of dietary tannins were assessed
Sylwia Małgorzewicz et al.
International journal of molecular medicine, 31(3), 503-510 (2013-01-15)
Plasminogen activator inhibitor type-1 (PAI-1) inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which convert plasminogen to plasmin, a strong proteolytic enzyme. Thus, PAI-1 is a primary and negative regulator of plasmin-driven proteolysis. In addition to its main
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