U118
[Tyr0]Urocortin, rat
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About This Item
UNSPSC Code:
12352200
MDL number:
assay
>97%
form
lyophilized powder (hygroscopic)
mol wt
4872
storage condition
desiccated
UniProt accession no.
storage temp.
−20°C
Gene Information
rat ... Ucn(29151)
Application
Corticotropin-releasing factor (CRF) receptor ligand; precursor for production of radioiodinated urocortin.
Other Notes
Peptide content and salt form information are provided with each lot.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Jong-Whi Park et al.
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Sprouty2 (SPRY2), a feedback regulator of receptor tyrosine kinase (RTK) signaling, has been shown to be associated with drug resistance and cell proliferation in glioblastoma (GBM), but the underlying mechanisms are still poorly defined. SPRY2 expression and survival patterns of
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Treatment resistance of glioblastoma multiforme to chemo- and radiotherapy remains a challenge yet to overcome. In particular, the O6-methylguanine-DNA-methyltransferase (MGMT) promoter unmethylated patients have only little benefit from chemotherapy treatment using temozolomide since MGMT counteracts its therapeutic efficacy. Therefore, new
Sandy Mercurio et al.
Acta neuropathologica communications, 1, 17-17 (2013-11-21)
Pilocytic astrocytomas occur predominantly in childhood. In contrast to the posterior fossa location, hypothalamo-chiasmatic pilocytic astrocytomas display a worse prognosis often leading to multiple surgical procedures and/or several lines of chemotherapy and radiotherapy to achieve long-term control. Hypothalamo-chiasmatic pilocytic astrocytomas
J Vaughan et al.
Nature, 378(6554), 287-292 (1995-11-16)
Corticotropin-releasing factor (CRF), a peptide first isolated from mammalian brain, is critical in the regulation of the pituitary-adrenal axis, and in complementary stress-related endocrine, autonomic and behavioural responses. Fish urotensin I and amphibian sauvagine were considered to be homologues of
Pietri Puustinen et al.
Cancer research, 69(7), 2870-2877 (2009-03-19)
Extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway activity is regulated by the antagonist function of activating kinases and inactivating protein phosphatases. Sustained ERK pathway activity is commonly observed in human malignancies; however, the mechanisms by which the pathway is protected
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