U1755
Urapidil
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About This Item
Empirical Formula (Hill Notation):
C20H29N5O3
CAS Number:
Molecular Weight:
387.48
UNSPSC Code:
12352204
PubChem Substance ID:
EC Number:
252-130-4
MDL number:
SMILES string
COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
InChI
1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3
InChI key
ICMGLRUYEQNHPF-UHFFFAOYSA-N
Biochem/physiol Actions
α-Adrenergic antagonist; peripheral vasodilator;
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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B Tomlinson et al.
European journal of clinical pharmacology, 41(1), 1-3 (1991-01-01)
Intravenous urapidil, 40 mg bolus followed by an infusion of 18 mg.h-1 for 2 h was administered to 6 female non-patient volunteers. Randomised cumulative dose response curves to angiotensin, phenylephrine and isoprenaline were performed before and commencing 30 min after
R I Semenova et al.
Terapevticheskii arkhiv, 84(8), 72-74 (2012-09-22)
To evaluate the clinical efficacy of ebrantil used in patients with resistant arterial hypertension (RAH) in Stage III-V chronic kidney disease (CKD). Sixty-five patients with Stage III-V CKD and RAH (systolic blood pressure (SBP) 215.7 +/- 4.0 mm Hg and
[Hypertensive crisis in cardiology: place of urapidil].
Zh D Kobalava et al.
Kardiologiia, 52(1), 86-90 (2012-02-07)