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Merck
CN

U4760

Sigma-Aldrich

UR-AK57 dihydrochloride

≥98% (HPLC)

Synonym(s):

N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)-propyl]guanidine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H29N5O·2HCl
CAS Number:
902154-35-2
Molecular Weight:
392.37
MDL number:
MFCD17215973
UNSPSC Code:
12352200
PubChem Substance ID:
329827632
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Cl.CC(CC(=O)NC(=N)NCCCc1ncc[nH]1)C2CCCCC2

InChI

1S/C17H29N5O.2ClH/c1-13(14-6-3-2-4-7-14)12-16(23)22-17(18)21-9-5-8-15-19-10-11-20-15;;/h10-11,13-14H,2-9,12H2,1H3,(H,19,20)(H3,18,21,22,23);2*1H

InChI key

IBBYQLOGMIDRMM-UHFFFAOYSA-N

Biochem/physiol Actions

Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine.
Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine. Histamine receptors are GPCRS and have long been therapeutic targets for allergic rhinitis. In brain, histamine receptors are targets for psychotherapeutics.
UR-AK57 is known to function as an effective, partial histamine H1-receptor (H1R) and H2-receptor (H2R) agonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UR-AK57 dihydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
060M4611V

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Sheng-Xue Xie et al.
The Journal of pharmacology and experimental therapeutics, 317(3), 1262-1268 (2006-03-24)
Both the histamine H1-receptor (H1R) and H2-receptor (H2R) exhibit pronounced species selectivity in their pharmacological properties; i.e., bulky agonists possess higher potencies and efficacies at guinea pig (gp) than at the corresponding human (h) receptor isoforms. In this study, we

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