U7251
Uridine-5′-diphosphoglucose Dehydrogenase from bovine liver
Type VI, lyophilized powder, ≥0.1 units/mg protein
Synonym(s):
UDP-glucose:NAD+ 6-oxidoreductase
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About This Item
CAS Number:
UNSPSC Code:
12352204
EC Number:
232-826-4
MDL number:
type
Type VI
form
lyophilized powder
specific activity
≥0.1 units/mg protein
composition
Protein, 30-60%
storage temp.
−20°C
Biochem/physiol Actions
UDP-glucose 6-dehydrogenase, also known as uridine-5′-diphosphoglucose dehydrogenase, was shown to bind NAD and NADPH at a saturated amount of 0.5 mol and 2 mol respectively. The binding of UDP-glucose 6-dehydrogenase to NADPH was pH-dependent.
Physical form
Lyophilized powder containing ~30% potassium phosphate and ~20% sodium citrate
Analysis Note
Protein determined by Modified Warburg-Christian method.
Other Notes
One unit will oxidize 1.0 μmole of UDP-glucose to UDP-glucuronic acid per min at pH 8.7 at 25 °C.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Instructions
Naoki Izawa et al.
Journal of bioscience and bioengineering, 111(6), 665-670 (2011-03-05)
Generally recognized as safe, Streptococcus thermophilus was transformed using a plasmid expressing endogenous hyaluronic acid (HA) synthase genes. A single expression of hyaluronic acid synthase (hasA), uridine diphosphate-glucose dehydrogenase gene (hasB), or pyrophosphorylase gene (glmU) and double expression of hasA
Thomas Eixelsberger et al.
Carbohydrate research, 356, 209-214 (2012-04-25)
Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes the biosynthetic oxidation of UDP-glucose into UDP-glucuronic acid. The catalytic reaction proceeds in two NAD(+)-dependent steps via covalent thiohemiacetal and thioester enzyme intermediates. Formation of the thiohemiacetal adduct occurs through attack of Cys(276) on C-6
Chunyu Zhang et al.
Metabolic engineering, 14(5), 521-527 (2012-07-12)
As a precursor of bioengineered heparin, heparosan is currently produced from Escherichia coli K5, which is pathogenic bacteria potentially causing urinary tract infection. Thus, it would be advantageous to develop an alternative source of heparosan from a non-pathogeneic strain. In