U7253
Urotensin I teleost fish
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C210H340N62O67S2
CAS Number:
Molecular Weight:
4869.45
UNSPSC Code:
12352200
MDL number:
assay
≥95% (HPLC)
storage temp.
−20°C
Application
Urotensin I teleost fish was administered intracerebroventricularly in juvenile rainbow trout (Oncorhynchus mykiss) for studying the impact of corticotropin-releasing factor (CRF) and urotensin I on aggression and anxiety-like behaviour.
Biochem/physiol Actions
A neuroendocrine peptide of the CRF family that is found in the brain of most fish species. It may be involved in the regulation of blood pressure in fish. It is closely related to mammalian urocortin and releases ACTH from cultured rat pituitary cells.
Urotensin I is a CRF-like neuropeptide, expresses mainly in the brain of most fish species. It induces the acetylcholine (ACTH) release from the superfused goldfish anterior pituitary cell column. It stimulates the marked, dose-dependent reduction in perfusion pressure in the hind limb of the rat.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Effects and assay of urotensin I on the perfused hind limb of the rat.
K Lederis et al.
General and comparative endocrinology, 24(1), 10-16 (1974-09-01)
J Fryer et al.
Endocrinology, 113(6), 2308-2310 (1983-12-01)
Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion
J M Conlon
Regulatory peptides, 93(1-3), 3-12 (2000-10-18)
During the past 20 years, several bioactive peptides have been identified in teleost fishes that subsequently have been shown to play important regulatory roles in mammalian physiology. The urophysis, corpuscles of Stannius and Brockmann body are anatomical structures particular to
Tobias Backström et al.
The Journal of experimental biology, 214(Pt 6), 907-914 (2011-02-25)
Corticotropin-releasing factor (CRF) is central in the stress response but also modulates several behaviors including anxiety-related behaviors and aggression. In this study, juvenile rainbow trout (Oncorhynchus mykiss) were tested for competitive ability, determined during dyadic fights for dominance, after intracerebroventricular
N J Bernier et al.
General and comparative endocrinology, 116(3), 461-477 (1999-12-22)
Corticotropin-releasing factor (CRF) and urotensin I (UI) precursor cDNAs were cloned and sequenced from a goldfish brain cDNA library in order to investigate the distribution of CRF and UI mRNAs in goldfish brain and the regulation of CRF and UI
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