U7253
Urotensin I teleost fish
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C210H340N62O67S2
CAS Number:
Molecular Weight:
4869.45
MDL number:
UNSPSC Code:
12352200
Assay
≥95% (HPLC)
storage temp.
−20°C
Amino Acid Sequence
Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2
Application
Urotensin I teleost fish was administered intracerebroventricularly in juvenile rainbow trout (Oncorhynchus mykiss) for studying the impact of corticotropin-releasing factor (CRF) and urotensin I on aggression and anxiety-like behaviour.
Biochem/physiol Actions
A neuroendocrine peptide of the CRF family that is found in the brain of most fish species. It may be involved in the regulation of blood pressure in fish. It is closely related to mammalian urocortin and releases ACTH from cultured rat pituitary cells.
Urotensin I is a CRF-like neuropeptide, expresses mainly in the brain of most fish species. It induces the acetylcholine (ACTH) release from the superfused goldfish anterior pituitary cell column. It stimulates the marked, dose-dependent reduction in perfusion pressure in the hind limb of the rat.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Tobias Backström et al.
The Journal of experimental biology, 214(Pt 6), 907-914 (2011-02-25)
Corticotropin-releasing factor (CRF) is central in the stress response but also modulates several behaviors including anxiety-related behaviors and aggression. In this study, juvenile rainbow trout (Oncorhynchus mykiss) were tested for competitive ability, determined during dyadic fights for dominance, after intracerebroventricular
N J Bernier et al.
General and comparative endocrinology, 116(3), 461-477 (1999-12-22)
Corticotropin-releasing factor (CRF) and urotensin I (UI) precursor cDNAs were cloned and sequenced from a goldfish brain cDNA library in order to investigate the distribution of CRF and UI mRNAs in goldfish brain and the regulation of CRF and UI
N Mimassi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 279(2), R484-R491 (2000-08-12)
The cardiovascular effects of centrally and peripherally administered synthetic trout urotensin (U)-I, a member of the corticotropin-releasing hormone family of neuroendocrine peptides, were investigated in unanesthetized rainbow trout Oncorhynchus mykiss. Intracerebroventricular injections of U-I (5.0 and 12.5 pmol) produced a
Effects and assay of urotensin I on the perfused hind limb of the rat.
K Lederis et al.
General and comparative endocrinology, 24(1), 10-16 (1974-09-01)
J M Conlon
Regulatory peptides, 93(1-3), 3-12 (2000-10-18)
During the past 20 years, several bioactive peptides have been identified in teleost fishes that subsequently have been shown to play important regulatory roles in mammalian physiology. The urophysis, corpuscles of Stannius and Brockmann body are anatomical structures particular to
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