U7504
UDP-Glucuronosyltransferase 1A7 Isozyme human
recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution, ≥0.15 units/mg protein
Synonym(s):
UDP-glycosyltransferase, UGT1A7
recombinant
expressed in baculovirus infected Sf9 cells
form
buffered aqueous glycerol solution
specific activity
≥0.15 units/mg protein
concentration
2-20 mg/mL protein
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... UGT1A7(54577)
General description
Greater than 80% of the activity was observed after the microsomes had undergone five freeze-thaw cycles.
UGT1A7 catalyzes the glucuronidation of phenolic xenobiotics.
Biochem/physiol Actions
A family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
Physical form
Microsomal fraction in 100 mM potassium phosphate, pH 7.4, 20% (v/v) glycerol, 0.1 mM EDTA, 1 mM DTT
Other Notes
One unit will transfer one nanomole of glucuronic acid from uridine-5′-diphosphoglucuronic acid to octyl gallate per minute at pH 7.5 at 37 °C.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Hye Young Ji et al.
Archives of pharmacal research, 36(1), 1-5 (2013-02-02)
DA-9801, the mixture extract of Dioscoreae rhizoma and Dioscorea nipponica Makino, is a new herbal drug currently being evaluated in a phase II clinical study for the treatment of diabetic peripheral neuropathy in Korea. The inhibitory potentials of DA-9801, D.
UGT2B17 as a disease accelerator in CLL.
Yiming Zhong et al.
Blood, 121(7), 1067-1068 (2013-02-16)
[Meulengracht disease].
Jonas Zeitz et al.
Praxis, 102(3), 129-135 (2013-02-07)
Cong Liu et al.
Fitoterapia, 83(8), 1415-1419 (2013-01-23)
Deoxyschizandrin and schisantherin A are major bioactive lignans isolated from Fructusschisandrae which has been widely used as a tonic in traditional Chinese medicine for manyyears. Inhibition of UDP-glucuronosyltransferases (UGTs) by herbal components might be animportant reason for clinical herb–drug interaction.
Cyril Bigo et al.
Drug metabolism reviews, 45(1), 34-47 (2013-01-22)
The recent progresses in molecular biology and pharmacology approaches allowed the characterization of a series of nuclear receptors (NRs) as efficient regulators of uridine diphosphate glucuronosyltransferase (UGT) genes activity. These regulatory processes ensure an optimized UGT expression in response to
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