U8382
Ubiquitin Conjugating Enzyme Fractions mammalian
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
UNSPSC Code:
12352200
MDL number:
Form:
solution
Biological source:
rabbit
biological source
rabbit
form
solution
technique(s)
ligand binding assay: suitable
shipped in
dry ice
storage temp.
−70°C
General description
Manufactured for Sigma by Boston Biochem., Inc.
Application
Ubiquitin Conjugating Enzyme Fractions mammalian may be used in transferring the activated ubiquitin from E1 to the substrate through an additional high energy thiol ester intermediate E2-S-ubiquitin.
Biochem/physiol Actions
Full complement of purified conjugation enzymes (E1, E2s, and E3s) that are found in mammalian Fraction II.
Ubiquitin Conjugating Enzyme Fractions mammalian signifies the full complement of purified conjugation enzymes (E1, E2s, and E3s), which are found in mammalian Fraction II. Ubiquitin conjugating enzyme facilitates the stimulation of IκB kinase complex by TRAF6. It also assists in assembly of novel polyubiquitin chains for DNA repair.
Storage Class
10 - Combustible liquids
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
D Ganoth et al.
The Journal of biological chemistry, 263(25), 12412-12419 (1988-09-05)
It was found previously that proteins conjugated to ubiquitin are degraded by an ATP-dependent enzyme system, but the mode of action of this system was unknown. We have resolved from reticulocyte extracts three factors that are required for the ATP-dependent
L Deng et al.
Cell, 103(2), 351-361 (2000-11-01)
TRAF6 is a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. We have purified a heterodimeric protein complex that links TRAF6 to IKK activation. Peptide mass fingerprinting analysis reveals that this complex
R M Hofmann et al.
Cell, 96(5), 645-653 (1999-03-25)
Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue. The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae. We show that Mms2p forms a specific heteromeric