U8504
UDP-Glucuronosyltransferase 2B7 Isozyme human
recombinant, expressed in baculovirus infected Sf9 cells, ≥0.067 units/mg protein, buffered aqueous glycerol solution
Synonym(s):
UDP-glycosyltransferase 2B7, Isozyme human, UGT 2B7 Isozyme, Microsomes human
recombinant
expressed in baculovirus infected Sf9 cells
form
buffered aqueous glycerol solution
specific activity
≥0.067 units/mg protein
concentration
2-20 mg/mL protein
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... UGT2B7(7364)
General description
UGT2B7 transfers glucuronide to steroids, morphine, AZT, and retinoic acid.
Biochem/physiol Actions
A family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
Physical form
Microsomal fraction in 100 mM potassium phosphate, pH 7.4, 20% (v/v) glycerol, 0.1 mM EDTA, and 1 mM DTT.
Analysis Note
Greater than 90% of the activity remained after five freeze-thaw cycles.
Other Notes
One unit will transfer one nanomole of glucuronic acid from uridine-5′-diphosphoglucuronic acid to hyodeoxycholic acid per minute at pH 7.5 at 37 °C.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Cyril Bigo et al.
Drug metabolism reviews, 45(1), 34-47 (2013-01-22)
The recent progresses in molecular biology and pharmacology approaches allowed the characterization of a series of nuclear receptors (NRs) as efficient regulators of uridine diphosphate glucuronosyltransferase (UGT) genes activity. These regulatory processes ensure an optimized UGT expression in response to
Cong Liu et al.
Fitoterapia, 83(8), 1415-1419 (2013-01-23)
Deoxyschizandrin and schisantherin A are major bioactive lignans isolated from Fructusschisandrae which has been widely used as a tonic in traditional Chinese medicine for manyyears. Inhibition of UDP-glucuronosyltransferases (UGTs) by herbal components might be animportant reason for clinical herb–drug interaction.
Hye Young Ji et al.
Archives of pharmacal research, 36(1), 1-5 (2013-02-02)
DA-9801, the mixture extract of Dioscoreae rhizoma and Dioscorea nipponica Makino, is a new herbal drug currently being evaluated in a phase II clinical study for the treatment of diabetic peripheral neuropathy in Korea. The inhibitory potentials of DA-9801, D.
[Meulengracht disease].
Jonas Zeitz et al.
Praxis, 102(3), 129-135 (2013-02-07)
UGT2B17 as a disease accelerator in CLL.
Yiming Zhong et al.
Blood, 121(7), 1067-1068 (2013-02-16)
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