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Merck
CN

U8632

Sigma-Aldrich

Ubiquitin-Carrier Protein H5a, GST-tagged human

≥95% (SDS-PAGE), liquid

Synonym(s):

UbcH5a human

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About This Item

MDL number:
UNSPSC Code:
12352202
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recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

mol wt

47 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

General description

Manufactured for Sigma by Boston Biochem., Inc.

Biochem/physiol Actions

Human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer.
Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.

Physical form

Solution in 50 mM HEPES, pH 8.0, 100 mM NaCl, 1 mM DTT in 10% glycerol.

Storage Class Code

12 - Non Combustible Liquids

Regulatory Information

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The ubiquitin-proteasome proteolytic pathway.
A Ciechanover
Cell, 79(1), 13-21 (1994-10-07)

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