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Merck
CN

UC160

Sigma-Aldrich

4-Hydroxytolbutamide

≥98% (HPLC)

Synonym(s):

N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide

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10 MG
¥278.33
25 G
¥550.89
100 G
¥1,007.80
1 KG
¥5,319.58

¥278.33


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10 MG
¥278.33
25 G
¥550.89
100 G
¥1,007.80
1 KG
¥5,319.58

About This Item

Empirical Formula (Hill Notation):
C12H18N2O4S
CAS Number:
Molecular Weight:
286.35
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77

¥278.33


In StockDetails


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Assay

≥98% (HPLC)

form

solid

color

white

mp

100-102 °C

solubility

ethanol: soluble 12 mg/mL
0.1 M NaOH: soluble 4 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1

InChI

1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)

InChI key

SJRHYONYKZIRPM-UHFFFAOYSA-N

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1 of 4

This Item
A762705129PHL80344
form

powder

form

powder

form

powder or crystals

form

solid

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

assay

98.5-101.0%

assay

≥98% (TLC)

assay

≥99.5% (NT)

assay

≥98.0% (HPLC)

product line

BioXtra

product line

-

product line

BioUltra

product line

phyproof® Reference Substance

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

solubility

H2O: 100 mg/mL

solubility

H2O: 50 mg/mL, clear, colorless

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

-

Application

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide[1].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Metabolite of tolbutamide; formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.

Preparation Note

4-Hydroxytolbutamide is soluble in ethanol at 12 mg/mL and is also soluble in 0.1 M NaOH at 4 mg/ml. It is insoluble in water.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1) (2009)
A primary culture technique of adult retina for regeneration studies on adult CNS neurons
Alexandra Kretz
Nature Protocols, 131-140 (2007)
Serial Cultivation of Primary Adult Murine Keratinocytes
Richard P. Redvers and Pritinder Kaur
Methods in Molecular Biology, 15-22 (2005)
Alanine and Glutamine Synthesis and Release from Skeletal
Muscle
ALAN J. GARBER
The Journal of Biological Chemistry, 251(3) (1976)
Muscle alanine synthesis and hepatic gluconeogenesis
Snell K
Biochemical Society Transactions, 8(2), 205-213 (1980)

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