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Merck
CN

UC440

Benzydamine N-oxide hydrogen maleate

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About This Item

Empirical Formula (Hill Notation):
C19H23N3O2·C4H4O4
CAS Number:
72962-60-8
Molecular Weight:
441.48
PubChem Substance ID:
329827669
UNSPSC Code:
12161501

Key Documents

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InChI

1S/C19H23N3O2.C4H4O4/c1-22(2,23)13-8-14-24-19-17-11-6-7-12-18(17)21(20-19)15-16-9-4-3-5-10-16;5-3(6)1-2-4(7)8/h3-7,9-12H,8,13-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

QFAFNBZWRXPMSY-BTJKTKAUSA-N

SMILES string

OC(=O)\C=C/C(O)=O.C[N+](C)([O-])CCCOc1nn(Cc2ccccc2)c3ccccc13

form

solid

color

white to off-white

mp

94-95 °C

storage temp.

2-8°C

Application

Benzydamine N-oxide hydrogen maleate can be used for spectroscopic analyses.

Biochem/physiol Actions

CYP2C9 substrate

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
332-130-1
033M3901V
033M3901
332-130-1V
1435753

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A Santi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 32(1), 73-86 (2002-02-01)
1. Benzydamine (BZ), a non-steroidal anti-inflammatory drug used in human and veterinary medicine, is not licensed for use in food-producing species. Biotransformation of BZ in cattle has not been reported previously and is investigated here using liver microsomes and precision-cut
B Catanese et al.
Pharmacological research communications, 18(4), 385-403 (1986-04-01)
A method for the extraction and quantification of benzydamine and its metabolite N-oxide by liquid chromatography with fluorescence detection in plasma samples is described. This method has adequate sensitivity, specificity and is reproducible. The use of the extraction column allowed
Can caffeine metabolism be used as an in-vivo probe for human flavin-containing monooxygenase activity?
A E Rettie et al.
Pharmacogenetics, 10(3), 275-277 (2000-05-10)
G A Baldock et al.
Journal of chromatography, 529(1), 113-123 (1990-07-13)
A simple, sensitive and selective method for the determination of benzydamine in human plasma and urine, and for benzydamine N-oxide in urine, has been developed using high-performance liquid chromatography in the reversed-phase mode. The limit of reliable determination of benzydamine
A Kawaji et al.
Biochimica et biophysica acta, 1425(1), 41-46 (1998-11-14)
Benzydamine (BZY) N-oxidation mediated by flavin-containing monooxygenase (FMO) was evaluated in perfused brain and liver. Following 20 min of perfusion with modified Ringer solution, the infusion of BZY into brain or liver led to production of BZY N-oxide. BZY N-oxide
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