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V0882

D-Val-Leu-Lys 4-nitroanilide dihydrochloride

plasmin substrate

Synonym(s):

D-Val-Leu-Lys-pNA dihydrochloride, D-Valyl-L-leucyl-L-lysine 4-nitroanilide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H38N6O5 · 2HCl
CAS Number:
62354-43-2
Molecular Weight:
551.51
NACRES:
NA.32
PubChem Substance ID:
24900701
UNSPSC Code:
12352204
MDL number:
MFCD00077899
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Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow

storage temp.

−20°C

SMILES string

Cl.Cl.CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C23H38N6O5.2ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);2*1H/t18-,19-,20+;;/m0../s1

InChI key

VESQMNNSPPEOSZ-ZLARAOTRSA-N

Application

D-Val-Leu-Lys 4-nitroanilide dihydrochloride has been used as a chromogenic substrate to determine the formation of plasmin from plasminogen in amidolytic activity assay and plasminogen activating assay.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000545731
0000545734
0000545732
0000545731
0000545734

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Protocols

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

S Ueshima et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 7(5), 522-529 (1996-07-01)
Staphylokinase (SAK), produced by Staphylococcus aureus, induces fibrinolytic activity in circulation without systemic fibrinolytic activation. Since the effect of blood vessels on the activity of SAK has not yet been clarified, plasminogen activator (PA) activity of SAK in the presence
M Yamada et al.
Veterinary research communications, 21(2), 75-84 (1997-02-01)
An active fraction that accelerates plasminogen activation by tissue-type plasminogen activator (t-PA) was purified from a haemolysate of bovine erythrocytes. When the haemolysate was mixed with t-PA, it produced a 2- to 3-fold increase in plasminogen activation as measured by
K M Rippel et al.
Journal of dairy science, 87(8), 2344-2350 (2004-08-26)
The plasmin system native to bovine milk consists of the caseinolytic serine proteinase plasmin; its inactive zymogen, plasminogen; plasminogen activators; and inhibitors. Evidence in the literature indicates that whey proteins may inhibit plasmin activity, but there is very little mention
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Global Trade Item Number

SKUGTIN
V0882-25MG04061832927053
V0882-5MG04061837429033