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Merck
CN

V119

Supelco

Verruculogen

powder

Synonym(s):

1,10,10a,14,14a,15b-Hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-5H,12H-3,4-dioxa-5a,11a,15a-triazacyclooct[1m]indeno[5,6-b]fluorene-11,15(2H,13H)-dione, TR 1

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About This Item

MDL number:
MFCD00079645
UNSPSC Code:
41116107
PubChem Substance ID:
329829027

Key Documents

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form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

chloroform: 20 mg/mL

format

neat

storage temp.

−20°C

SMILES string

COc1ccc2c3[C@H](O)[C@]4(O)N([C@H]5CC(C)(C)OO[C@H](\C=C(\C)C)n(c35)c2c1)C(=O)[C@@H]6CCCN6C4=O

InChI

1S/C27H33N3O7/c1-14(2)11-20-29-18-12-15(35-5)8-9-16(18)21-22(29)19(13-26(3,4)37-36-20)30-24(32)17-7-6-10-28(17)25(33)27(30,34)23(21)31/h8-9,11-12,17,19-20,23,31,34H,6-7,10,13H2,1-5H3/t17-,19-,20+,23-,27+/m0/s1

InChI key

LRXYHMMJJCTUMY-GWXUGYLUSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Selective blocker of high conductance Ca2+-activated (Maxi-K) potassium channels.

Disclaimer

Photosensitive

Regulatory Information

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M I Selala et al.
Journal of natural products, 54(1), 207-212 (1991-01-01)
Paxilline was isolated from Penicillium paxilli (NRRL 6110). It was studied together with penitrem B and verruculogen in the electrically stimulated guinea pig ileum. All three mycotoxins enhanced the electrically induced twitch contractions, without influencing the contractions provoked by exogenous
H G Knaus et al.
Biochemistry, 33(19), 5819-5828 (1994-05-17)
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these fungal mycotoxins is not understood but may be related to their known effects on neurotransmitter release. To determine whether these effects could be

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