V1260
VEGF Receptor-3 (Flt-4)/Fc Chimera human
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
Vascular Endothelial Growth Factor Receptor‑3
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
human
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
calculated mol wt ~112 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FLT4(2324)
Application
VEGF Receptor-3 (Flt-4)/Fc chimera human is a disulfide-linked homodimeric protein that consists of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system.
Biochem/physiol Actions
VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 blocks VEGF-C/D and hence inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).
Physical form
Lyophilized from a 2 μm filtered solution in phosphate buffered saline.
Analysis Note
The binding affinity of recombinant VEGF R3 has not been determined. Its intended use is for western blot and ELISA standards.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer.
Molecular Cancer, 10 (2011)
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