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Merck
CN

V1260

Sigma-Aldrich

VEGF Receptor-3 (Flt-4)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Vascular Endothelial Growth Factor Receptor‑3

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About This Item

MDL number:
MFCD03101927
UNSPSC Code:
51111800

Key Documents

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biological source

human

recombinant

expressed in NSO cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt ~112 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

P35916

storage temp.

−20°C

Gene Information

human ... FLT4(2324)

Application

VEGF Receptor-3 (Flt-4)/Fc chimera human is a disulfide-linked homodimeric protein that consists of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system.

Biochem/physiol Actions

VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 blocks VEGF-C/D and hence inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).

Physical form

Lyophilized from a 2 μm filtered solution in phosphate buffered saline.

Analysis Note

The binding affinity of recombinant VEGF R3 has not been determined. Its intended use is for western blot and ELISA standards.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
100K0036

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Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer.
Molecular Cancer, 10 (2011)

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