V2005
[deamino-Pen1, Val4, D-Arg8]-Vasopressin
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C48H69N13O11S2
CAS Number:
Molecular Weight:
1068.27
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC(C)C1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC(=O)CC(C)(C)SSCC(NC(=O)C(CC(N)=O)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
Agonist at the V2 vasopressin receptor (antidiuretic) and antagonist at the V1 receptor (vasopressor).
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G Mazzocchi et al.
Neuropeptides, 24(2), 105-108 (1993-02-01)
Acute and chronic systemic administrations of neurotensin (NT) and arginine-vasopressin (AVP) significantly increases plasma aldosterone concentration (PAC) in rats. Deamino-Pen1, Val4, D-Arg8-vasopressin (AVP-A), a potent AVP antagonist, completely reversed both acute and chronic aldosterone secretagogue actions of NT and AVP.
Wei Wei et al.
The Annals of thoracic surgery, 73(2), 516-522 (2002-02-16)
Arginine vasopressin (AVP) has recently been demonstrated as an alternative in the treatment of severe refractory vasodilatation in coronary artery bypass grafting. However, AVP may be a spasmogen for graft spasm. We compared the in vitro antispastic effect among calcium-channel
J R McNeill
Canadian journal of physiology and pharmacology, 61(7), 770-773 (1983-07-01)
[1-deaminopenicillamine, 4-valine, 8-D-arginine]Vasopressin (DPVDAVP), a specific antagonist of the pressor activity of vasopressin, and teprotide, a converting enzyme inhibitor, were infused intravenously in conscious, fasted (24-30 h) but not water-deprived cats which had been implanted previously with flow probes on
G Mazzocchi et al.
The Journal of steroid biochemistry and molecular biology, 45(4), 251-256 (1993-04-01)
A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen1, Val4, D-Arg8]-vasopressin (AVP-A; 3 nmol.kg-1 x min-1) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone. Prolonged AVP-A treatment caused a marked atrophy of
L Bueno et al.
The American journal of physiology, 262(3 Pt 1), G427-G431 (1992-03-01)
The effects of emotional stress (ES) corresponding to conditioned fear on colonic motility and its antagonism by [deamino-Pen1, Val4, D-Arg8]vasopressin, a vasopressin antagonist, were investigated by electromyography in conscious fasted rats fitted with chronically implanted electrodes. A 117% increase (19.6
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