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Merck
CN

V4265

VU 590 dihydrochloride hydrate

≥ (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C24H32N4O7·2HCl · xH2O
Molecular Weight:
561.46 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
329829050
MDL number:
MFCD16875439

Key Documents

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InChI

1S/C24H32N4O7.2ClH.H2O/c29-27(30)23-5-1-21(2-6-23)19-25-9-13-33-14-10-26(12-16-35-18-17-34-15-11-25)20-22-3-7-24(8-4-22)28(31)32;;;/h1-8H,9-20H2;2*1H;1H2

SMILES string

O.Cl.Cl.[O-][N+](=O)c1ccc(CN2CCOCCOCCN(CCOCC2)Cc3ccc(cc3)[N+]([O-])=O)cc1

InChI key

UARRNDBWOZCTNV-UHFFFAOYSA-N

form

solid

storage condition

desiccated

solubility

deionized water: >10 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1
VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1 at low micromolar affinity, but it does not inhibit Kir2.1 or Kir4.1. VU590 appears to act by blocking the ion permeation pathway of the channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
109K4610

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