V5390
VU0029251
≥98% (HPLC), powder
Synonym(s):
6,7-Dihydro-2-(methylthio)-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
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About This Item
Empirical Formula (Hill Notation):
C10H11N3S2
Molecular Weight:
237.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H11N3S2/c1-14-10-12-8(11)7-5-3-2-4-6(5)15-9(7)13-10/h2-4H2,1H3,(H2,11,12,13)
SMILES string
CSc1nc(N)c2c3CCCc3sc2n1
InChI key
WDDBZCKBRCTSOZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥11 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
VU0029251 is the first example of a partial mGluR5 partial antagonist that is not based on the MPEP scaffold.
VU0029251 is the first example of a partial mGluR5 partial antagonist that is not based on the MPEP scaffold. The compound displays a maximum inhibition of 50% activity, and cannot completely displace [3H] MPEP, suggesting that competition for MPEP is also allosteric, involving a unique site.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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