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V6258

D-Val-Leu-Arg p-nitroanilide diacetate salt

Name: <SC>D</SC>-Val-Leu-Arg p-nitroanilide diacetate salt
Brand: SIGMA

≥95% (HPLC), suitable for ligand binding assays

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₈N₈O₅· 2 C₂H₄O₂

CAS Number:

64816-14-4

Molecular Weight:

626.70

UNSPSC Code:

12352209

PubChem Substance ID:

329829059

NACRES:

NA.26

MDL number:

MFCD09250882

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Product Name

D-Val-Leu-Arg p-nitroanilide diacetate salt, ≥95% (HPLC)

Quality Level

200

assay

≥95% (HPLC)

form

powder

composition

Peptide content, ~70%

technique(s)

ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

CC(O)=O.CC(O)=O.N[C@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O)=O

InChI

1S/C23H38N8O5.2C2H4O2/c1-13(2)12-18(30-22(34)19(24)14(3)4)21(33)29-17(6-5-11-27-23(25)26)20(32)28-15-7-9-16(10-8-15)31(35)36;2*1-2(3)4/h7-10,13-14,17-19H,5-6,11-12,24H2,1-4H3,(H,28,32)(H,29,33)(H,30,34)(H4,25,26,27);2*1H3,(H,3,4)/t17-,18-,19+;;/m0../s1

InChI key

WGVZWNUZAXIGKU-HYKWBEMSSA-N

Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Amino Acids – Building Blocks of Life Science

Application

D-Val-Leu-Arg p-nitroanilide diacetate salt has been used as a substrate to determine the amidolytic activity of the fibrinolytic enzyme from Bacillus subtilis DC33. It has also been used as a substrate to determine the activity of fibrinolytic enzymes from the earthworm Eisenia fetida.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Salt content will vary.

pictograms

GHS08

signalword

Warning

hcodes

H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

常规特殊物品

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Increase in ovarian kallikrein activity during ovulation in the gonadotrophin-primed immature rat.

Espey LL, Tanaka N, Winn V, Okamura H.

J. Reprod. Fert., 87, 503-508 (1989)

Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi

Cheng Tao Wang

Journal of Industrial Microbiology & Biotechnology, 33, 750-758 (2006)

Kinetic mechanism of the inhibition of human urinary kallikrein by basic pancreatic trypsin inhibitor.

T L Miranda et al.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 28(5), 505-512 (1995-05-01)

Hydrolysis of D-valyl-L-leucyl-L-arginine p-nitroanilide (D-Val-Leu-Arg-Nan) at five different concentrations (10-20 microM) by human urinary kallikrein was studied in the absence and in the presence of increasing concentrations of basic pancreatic trypsin inhibitor (BPTI) (1.35-9.15 nM). The data indicate that the

Kinetic characterization of rat tissue kallikrein using N alpha-substituted arginine 4-nitroanilides and N alpha-benzoyl-L-arginine ethyl ester as substrates.

M O Sousa et al.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 29(3), 327-334 (1996-03-01)

Hydrolysis of seven N alpha-substituted L-arginine 4-nitroanilides: benzoyl-arginine p-nitroanilide (Bz-Arg-Nan), tosyl-arginine p-nitroanilide (Tos-Arg-Nan), acetyl-leucyl-arginine p-nitroanilide (Ac-Leu-Arg-Nan), acetyl-phenylalanyl-arginine p-nitroanilide (Ac-Phe-Arg-Nan), benzoyl-phenylalanyl-arginine p-nitroanilide (Bz-Phe-Arg-Nan), tosyl-phenylalanyl-arginine p-nitroanilide (Tos-Phe-Arg-Nan), and D-valyl-leucyl-arginine p-nitroanilide (D-Val-Leu-Arg-Nan), and the N alpha-substituted L-arginine ester: benzoyl-arginine ethyl ester (Bz-Arg-OEt), by

MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity.

József Dobó et al.

Journal of immunology (Baltimore, Md. : 1950), 183(2), 1207-1214 (2009-07-01)

Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 is an abundant component of the lectin pathway of complement. The related enzyme, MASP-2 is capable of activating the complement cascade alone. Though the concentration of MASP-1 far exceeds that of MASP-2, only a

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Global Trade Item Number

SKU	GTIN
V6258-5MG	04061835550524

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