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Merck
CN

V6505

Sigma-Aldrich

Valosin Porcine

≥97% (HPLC)

Synonym(s):

Peptide VQY, Val-Gln-Tyr-Pro-Val-Glu-His-Pro-Asp-Lys-Phe-Leu-Lys-Phe-Gly-Met-Thr-Pro-Ser-Lys-Gly-Val-Leu-Phe-Tyr

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About This Item

Empirical Formula (Hill Notation):
C141H207N31O35S
CAS Number:
99510-37-9
Molecular Weight:
2928.40
MDL number:
MFCD00133919
UNSPSC Code:
12352202
PubChem Substance ID:
24900761
NACRES:
NA.26

Key Documents

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Assay

≥97% (HPLC)

UniProt accession no.

P03974

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(CC(O)=O)NC(=O)C3CCCN3C(=O)C(Cc4cnc[nH]4)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C5CCCN5C(=O)C(Cc6ccc(O)cc6)NC(=O)C(CCC(N)=O)NC(=O)C(N)C(C)C)C(C)C)C(=O)NC(C(C)O)C(=O)N7CCCC7C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(Cc8ccccc8)C(=O)NC(Cc9ccc(O)cc9)C(O)=O

InChI

1S/C141H207N31O35S/c1-77(2)63-97(157-128(193)100(66-84-33-18-14-19-34-84)159-122(187)93(39-24-27-58-144)154-130(195)102(71-114(182)183)161-132(197)107-40-28-59-170(107)139(204)104(70-88-72-147-76-150-88)164-124(189)95(52-54-113(180)181)156-137(202)117(81(9)10)168-134(199)109-42-29-60-171(109)138(203)103(68-86-43-47-89(175)48-44-86)163-123(188)94(51-53-110(145)177)155-135(200)115(146)79(5)6)126(191)153-92(38-23-26-57-143)121(186)158-99(65-83-31-16-13-17-32-83)120(185)149-73-111(178)151-96(55-62-208-12)125(190)169-118(82(11)174)140(205)172-61-30-41-108(172)133(198)166-106(75-173)131(196)152-91(37-22-25-56-142)119(184)148-74-112(179)167-116(80(7)8)136(201)162-98(64-78(3)4)127(192)160-101(67-85-35-20-15-21-36-85)129(194)165-105(141(206)207)69-87-45-49-90(176)50-46-87/h13-21,31-36,43-50,72,76-82,91-109,115-118,173-176H,22-30,37-42,51-71,73-75,142-144,146H2,1-12H3,(H2,145,177)(H,147,150)(H,148,184)(H,149,185)(H,151,178)(H,152,196)(H,153,191)(H,154,195)(H,155,200)(H,156,202)(H,157,193)(H,158,186)(H,159,187)(H,160,192)(H,161,197)(H,162,201)(H,163,188)(H,164,189)(H,165,194)(H,166,198)(H,167,179)(H,168,199)(H,169,190)(H,180,181)(H,182,183)(H,206,207)

InChI key

OVSVDLZVCMFSDM-UHFFFAOYSA-N

Gene Information

pig ... VCP(397524)

Biochem/physiol Actions

Stimulates pancreatic secretion.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
119H1420
119H14201
016H1590
016H15901
057F06681

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W E Schmidt et al.
FEBS letters, 191(2), 264-268 (1985-10-28)
The isolation and primary structure of a novel gastrointestinal peptide, designated valosin, is described. The peptide was purified from porcine upper gut extracts using an HPLC and N-terminal sequence screening strategy which depends on chromatographic and structural characteristics as isolation
Valosin stimulates gastric and exocrine pancreatic secretion and inhibits fasting small intestinal myoelectric activity in the dog.
Konturek SJ, Schmidt WE, et al.
Gastroenterologie Clinique Et Biologique, 92, 1181-1186 (1987)
Petra Hänzelmann et al.
The Journal of biological chemistry, 286(44), 38679-38690 (2011-09-15)
The AAA (ATPase associated with various cellular activities) ATPase p97, also referred to as valosin-containing protein (VCP), mediates essential cellular processes, including ubiquitin-dependent protein degradation, and has been linked to several human proteinopathies. p97 interacts with multiple cofactors via its

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