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Merck
CN

WH0007453M2

Sigma-Aldrich

Monoclonal Anti-WARS antibody produced in mouse

clone 3A12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-GAMMA2, Anti-IFI53, Anti-IFP53, Anti-tryptophanyl-tRNA synthetase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A12, monoclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

technique(s)

immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_004184

UniProt accession no.

P23381

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... WARS(7453)

General description

Tryptophanyl-tRNA synthetase, cytoplasmic (WARS) or IFP53 is the cytoplasmic form of tryptophanyl-tRNA synthetase. It is induced by interferons and the gene encoding it is localized on human chromosome 14q32.31.

Immunogen

WARS (NP_004175, 50 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
YKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDA

Biochem/physiol Actions

Tryptophanyl-tRNA synthetase, cytoplasmic (WARS) is involved in the tryptophan aminoacylation of tRNAtrp. Mutations in the gene encoding it have been associated with distal hereditary motor neuropathy.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
07180-3A12

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A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy.
Tsai PC
Brain (2017)
Assignment of the human tryptophanyl-tRNA synthetase gene (WARS) to chromosome 14q32.2?q32.32
B?rglum A.D
Cytogenetic and genome research (1993)

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