WH0051621M1
Monoclonal Anti-KLF13 antibody produced in mouse
clone 1D3, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-BTEB3, Anti-FKLF2, Anti-Kruppel-like factor 13, Anti-NSLP1, Anti-RFLAT1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
1D3, monoclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
technique(s)
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KLF13(51621)
General description
KLF13 belongs to a family of transcription factors that contain three classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).
RFLAT-1/KLF13 (kruppel like factor 13) belongs to the krüppel-like family of transcription factors. This gene is located on human chromosome 15q13.
Immunogen
KLF13 (AAH13946, 31 a.a. ~ 72 a.a) partial recombinant protein.
Sequence
PESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLN
Sequence
PESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLN
Application
Monoclonal Anti-KLF13 antibody has been used in immunoblotting.
Biochem/physiol Actions
RFLAT-1/KLF13 (kruppel like factor 13) controls the life cycle of papillomavirus in keratinocytes through STAT5 (signal transducer and activator of transcription 5) and IL-8 (interleukin-8). It participates in cardiac gene transcription and heart development.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8
Zhang W, et al.
Oncogene, 35(42), 5565-5575 (2016)
Clinical utility gene card for: 15q13.3 microdeletion syndrome
Tropeano M, et al.
European Journal of Human Genetics, 22(11), 1338-1338 (2014)
A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes
Bayoumi AS, et al.
Journal of Molecular and Cellular Cardiology, 114, 72-82 (2018)
Ahmed S Bayoumi et al.
Journal of molecular and cellular cardiology, 114, 72-82 (2017-11-11)
Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs), small non-coding RNAs that post-transcriptionally regulate target genes. MiR-125b-5p is downregulated in patients with end-stage dilated and ischemic cardiomyopathy, and has been proposed as a biomarker of
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