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Merck
CN

WH0161582M9

Sigma-Aldrich

Monoclonal Anti-DYX1C1 antibody produced in mouse

clone 6G1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-DYX1, Anti-DYXC1, Anti-EKN1, Anti-FLJ37882, Anti-MGC70618, Anti-dyslexia susceptibility 1 candidate 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6G1, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

NM_130810

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DYX1C1(161582)

General description

Dyslexia susceptibility 1 candidate 1 (DYX1C1) is a 420 amino acid protein. The gene encoding it localized on human chromosome 15q21 and consists of 10 exons.

Immunogen

DYX1C1 (NP_570722, 336 a.a. ~ 420 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVIQGTELKS

Biochem/physiol Actions

Dyslexia susceptibility 1 candidate 1 (DYX1C1) associates with estrogen receptors. It has a role in neuronal migration and has been linked to developmental dyslexia.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
07205-6G1

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C Tran et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 162B(2), 146-156 (2013-01-24)
Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms
Shyamala K Venkatesh et al.
Psychiatric genetics, 24(1), 10-20 (2013-12-24)
DYX1C1 has been identified as a susceptible candidate gene for developmental dyslexia (DD); studies in various populations have yielded inconclusive results and the causal allele is unknown in the Indian population. On the basis of the initial association studies and
T C Bates et al.
Molecular psychiatry, 15(12), 1190-1196 (2009-11-11)
The status of DYX1C1 (C15q21.3) as a susceptibility gene for dyslexia is unclear. We report the association of this gene with reading and spelling ability in a sample of adolescent twins and their siblings. Family-based association analyses were carried out
Gustaf Rosin et al.
BMC cancer, 12, 79-79 (2012-03-02)
The dyslexia candidate gene, DYX1C1, shown to regulate and interact with estrogen receptors and involved in the regulation of neuronal migration, has recently been proposed as a putative cancer biomarker. This study was undertaken to assess the prognostic value and

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