WH0388585M1
Monoclonal Anti-HES5 antibody produced in mouse
clone 3C5, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-hairy and enhancer of split 5 (Drosophila)
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About This Item
Conjugate:
unconjugated
Clone:
3C5, monoclonal
Application:
ELISA (i), WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3C5, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2bκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HES5(388585)
General description
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. (provided by RefSeq)
Immunogen
HES5 (NP_001010926, 28 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQR
Sequence
RRDRINSSIEQLKLLLEQEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKLLYHFQR
Biochem/physiol Actions
Hes family bHLH transcription factor 5 (HES5) is a regulator of Wnt family member 3A (Wnt-3A) protein. It is involved in stimulating the proliferation and differentiation of hepatocellular carcinoma cells. Methylation of the HES5 promoter has been studied to have a link with prostate cancer.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Massie CE
Endocrine-Related Cancer, 22(2), 131-144 (2015)
HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
Zhu G
Experimental and Molecular Pathology, 99(3), 474-484 (2015)
HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.
Mubmann C
Stem Cells and Development, 23(12), 1328-1339 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| WH0388585M1-100UG | 04061831621907 |