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Merck
CN

Y0271

Sigma-Aldrich

Anti-YB-1 (N-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-BP-8, Anti-CSDA2, Anti-CSDB, Anti-DBPB, Anti-MDR-NF1, Anti-NSEP1, Anti-Y BOX binding protein 1, Anti-YBOX1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa (An additional weaker band may be seen in some extract preparations.)

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

western blot: 0.5-1 μg/mL using PC-12 cell lysates
western blot: 1-2 μg/mL using HEK-293T or NIH-3T3 cell lysates

UniProt accession no.

P67809

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... YBX1(4904)
mouse ... Ybx1(22608)
rat ... Ybx1(500538)

General description

YB-1 (Y-box-binding protein 1) is a member of the evolutionary conserved Cold-Sock Domain (CSD) proteins. It is ubiquitously expressed in adult tissues and throughout embryogenesis.

Immunogen

synthetic peptide corresponding to amino acidds 137-150 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse proteins.

Application

Anti-YB-1 (N-terminal) antibody has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

YB-1 (Y-box-binding protein 1) plays a major role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance and stress responses. YB-1 deficient embryos die during late embryonic development and exhibit a runting phenotype.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086M4808V
058K4856

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The major mRNA-associated protein YB-1 is a potent 5? cap-dependent mRNA stabilizer
Evdokimova V, et al.
The Embo Journal, 20(19), 5491-5502 (2001)
The atypical dual specificity phosphatase hYVH1 associates with multiple Ribonucleoprotein particles
Geng Q, et al.
The Journal of biological chemistry, 292(2), 539-550 (2017)
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence
Lu Z H, et al.
Molecular and Cellular Biology, 25(11), 4625-4637 (2005)
Qiudi Geng et al.
The Journal of biological chemistry, 292(2), 539-550 (2016-11-20)
Human YVH1 (hYVH1), also known as dual specificity phosphatase 12 (DUSP12), is a poorly characterized atypical dual specificity phosphatase widely conserved throughout evolution. Recent findings have demonstrated that hYVH1 expression affects cellular DNA content and is a novel cell survival

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