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Merck
CN

Y1396

YFLLRNP trifluoroacetate

≥98%

Synonym(s):

L-Tyrosyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-Proline, Tyr-Phe-Leu-Leu-Arg-Asn-Pro, YFLLRNP-OH

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About This Item

Empirical Formula (Hill Notation):
C45H67N11O10 · xC2HF3O2
Molecular Weight:
922.08 (free base basis)
NACRES:
NA.32
PubChem Substance ID:
329831587
UNSPSC Code:
51111800
MDL number:
MFCD16879019

Key Documents

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InChI

1S/C45H67N11O10.C2HF3O2/c1-25(2)20-32(40(61)51-31(12-8-18-50-45(48)49)39(60)55-35(24-37(47)58)43(64)56-19-9-13-36(56)44(65)66)53-41(62)33(21-26(3)4)54-42(63)34(23-27-10-6-5-7-11-27)52-38(59)30(46)22-28-14-16-29(57)17-15-28;3-2(4,5)1(6)7/h5-7,10-11,14-17,25-26,30-36,57H,8-9,12-13,18-24,46H2,1-4H3,(H2,47,58)(H,51,61)(H,52,59)(H,53,62)(H,54,63)(H,55,60)(H,65,66)(H4,48,49,50);(H,6,7)/t30-,31-,32-,33-,34-,35-,36-;/m0./s1

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N3CCC[C@H]3C(O)=O

InChI key

HMDRRCMAXMJXKF-WDYYMHPRSA-N

assay

≥98%

form

solid

solubility

deionized water: 1 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

Application

YFLLRNP trifluoroacetate may be used as a powerful tool for differentiating the numerous possible activation states of the platelet thrombin receptor.

Biochem/physiol Actions

YFLLRNP is a Galpha12/13-stimulating peptide that activates the alpha granule secretion due to costimulation with either ADP or serotonin/epinephrine.
YFLLRNP is a PAR-1-specific partial agonist.
YFLLRNP is a PAR-1-specific partial agonist. The compound selectively activates the G(12/13) signaling cascade resulting in platelet shape.

Preparation Note

YFLLRNP trifluoroacetate dissolves in deionized water at 1 mg/mL.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
010M4707

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T M Quinton et al.
Journal of thrombosis and haemostasis : JTH, 2(6), 978-984 (2004-05-14)
Alpha granule release plays an important role in propagating a hemostatic response upon platelet activation. We evaluated the ability of various agonists to cause alpha granule release in platelets. Alpha granule release was measured by determining P-selectin surface expression in

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