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Merck
CN

Z0292

α-Zearalanol

~98% (HPLC), powder, mycotoxin

Synonym(s):

2,4-Dihydroxy-6-(6α,10-dihydroxyundecyl)benzoic acid μ-lactone

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About This Item

Empirical Formula (Hill Notation):
C18H26O5
CAS Number:
26538-44-3
Molecular Weight:
322.40
NACRES:
NA.77
PubChem Substance ID:
24902163
UNSPSC Code:
12352200
EC Number:
247-769-0
MDL number:
MFCD00083519

Key Documents

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Product Name

α-Zearalanol, ~98% (HPLC)

InChI key

DWTTZBARDOXEAM-GXTWGEPZSA-N

InChI

1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1

SMILES string

C[C@H]1CCC[C@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1

biological source

synthetic (organic)

sterility

non-sterile

assay

~98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

UHPLC: suitable

solubility

methanol: 1.96-2.04 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Related Categories

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Repr. 2 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000486508
0000486508
0000447989
0000447989
0000196721

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C Mastri et al.
Journal of steroid biochemistry, 23(3), 279-289 (1985-09-01)
It is now well established that the mycotoxin zearalenone and some of its derivatives possess oestrogenic activity. In the present study, the binding characteristics of [3H]zearalanol (P-1496) to different classes of sites including [1] the oestrogen receptor, [2] the higher
Hongfeng Wang et al.
The Journal of reproduction and development, 58(3), 338-343 (2012-03-27)
Alpha-Zearalenol (α-ZEA) is one of derivatives from Zearalenone (ZEA) which impacts mammalian reproduction and development. Previous studies have shown that pigs are sensitive to the estradiol-like effects of α-ZEA. However, the effect of α-ZEA for the early embryonic development has
Yilong Dong et al.
European journal of pharmacology, 670(2-3), 392-398 (2011-09-29)
Although favorable effects of estrogen replacement therapy on Alzheimer's disease on postmenopausal women have been recognized, an associated increased incidence of uterine and breast tumors has jeopardized the clinical use of estrogen. Phytoestrogen α-zearalanol (α-ZAL) is a reductive product of
Han-Yun Hsieh et al.
Journal of the science of food and agriculture, 92(6), 1230-1237 (2011-10-21)
Zeranol (Z) is a semi-synthetic mycotoxin that is used in some countries as a growth-promoting agent in livestock. In view of the known oestrogenic actions by Z and certain Z analogues, significant concerns exist with regard to the presence of
Mario Thevis et al.
Drug testing and analysis, 3(11-12), 777-783 (2011-11-19)
Zeranol ((7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one, also referred to as 7α-zearalanol, Ralone®, Frideron®, Ralgro®, etc.) is a semi-synthetic estrogenic veterinary drug with growth-promoting properties. Its use regarding animal husbandry has been prohibited in the European Union since 1981 and, due to its anabolic effects
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