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Merck
CN

Z0502

Zaleplon

≥98% (HPLC), solid

Synonym(s):

CL-284846, N-[3-(3-Cyanopyrazolo-[1,5-a]pyrimidin-7-yl)phenyl)-N-ethylacetamide

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About This Item

Empirical Formula (Hill Notation):
C17H15N5O
CAS Number:
151319-34-5
Molecular Weight:
305.33
UNSPSC Code:
12352200
PubChem Substance ID:
329831599
MDL number:
MFCD00867990

Key Documents

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Product Name

Zaleplon, ≥98% (HPLC), solid

InChI

1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3

SMILES string

CCN(C(C)=O)c1cccc(c1)-c2ccnc3c(cnn23)C#N

InChI key

HUNXMJYCHXQEGX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; psychotrope (France); regulated under CDSA - not available from Sigma-Aldrich Canada

storage condition

desiccated
protect from light

color

white

solubility

DMSO: ~20 mg/mL
H2O: insoluble

storage temp.

2-8°C

Gene Information

human ... GABRA1(2554), GABRB1(2560), GABRG2(2566)

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Biochem/physiol Actions

Zaleplon is a non-benzodiazepine agonist at the benzodiazepine site of the GABAA receptor; sedative; hypnotic.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
018K4711V
018K4711

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Karthik Y Janga et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(2), 347-357 (2011-11-02)
The present systematic study focused to investigate the combined advantage of proliposomes and surface charge for improved oral delivery of zaleplon. The zaleplon loaded proliposomes were prepared using hydrogenated soyphosphatidylcholine (HSPC) and cholesterol (CHOL) in varying ratios, and the optimized
Kirsten Wiese Simonsen et al.
Journal of analytical toxicology, 34(6), 332-341 (2010-07-29)
An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for detection of 23 benzodiazepines and related compounds in whole blood was developed and validated. The method is used for screening and quantitation of benzodiazepines in whole blood received from autopsy cases
Monique A J Mets et al.
Sleep medicine reviews, 14(4), 259-267 (2010-02-23)
Disturbed body balance and standing steadiness are problematic for those who wake up at night or in the morning after using hypnotic drugs. As a result, falls and hip fractures are frequently reported in patients using sleep medication. A literature
Daniela Remane et al.
Analytical and bioanalytical chemistry, 401(4), 1341-1352 (2011-07-21)
For fast and reliable screening, identification, and quantification of as many analytes as possible, multi-analyte approaches are very useful in clinical and forensic toxicology. Using ultra high performance liquid chromatography-tandem mass spectrometry, such an approach has been developed for blood
Joseph Barbera et al.
Drug safety, 28(4), 301-318 (2005-03-24)
Insomnia is a heterogeneous, highly prevalent condition that is associated with a high level of psychiatric, physical, social and economic morbidity. The treatment of insomnia involves pharmacological and non-pharmacological interventions. The mainstay of pharmacological treatment of insomnia has been the
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