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Z2001

Zonisamide sodium salt

≥98% (HPLC), NO scavenger, powder

Synonym(s):

1,2-Benzisoxazole-3-methanesulfonamide sodium-potassium salt, Aleviatin sodium-potassium salt, Exceglan sodium-potassium salt, Excegram sodium-potassium salt

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About This Item

Empirical Formula (Hill Notation):
C8H7N2NaO3S
CAS Number:
68291-98-5
Molecular Weight:
234.21
UNSPSC Code:
12352200
PubChem Substance ID:
24278783
NACRES:
NA.77
MDL number:
MFCD01744844

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Product Name

Zonisamide sodium salt, ≥98% (HPLC), powder

SMILES string

[Na]NS(=O)(=O)Cc1noc2ccccc12

InChI key

ZVBIRPKGWOVBLG-UHFFFAOYSA-N

InChI

1S/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: >5 mg/mL

originator

Eisai

Quality Level

100

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Biochem/physiol Actions

Zonisamide sodium salt is an anti-epileptic and also scavenges nitric oxide (NO).
Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).

Features and Benefits

This compound was developed by Eisai. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000496732
0000496732
0000166036
0000166037
092M4607V

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Zonisamide for the treatment of self-inflicted dermatoses related to impulse control disorders.
Maria José Tribó et al.
Archives of dermatology, 148(6), 762-764 (2012-06-20)
J Y Chung et al.
New Zealand veterinary journal, 60(6), 357-359 (2012-05-30)
To evaluate the efficacy of zonisamide as a monotherapy in dogs with idiopathic epileptic seizure. The experiment was conducted on 10 dogs with idiopathic epilepsy that were treated at the Seoul National University Hospital for Animals. A diagnosis was conducted
Dong Wook Kim et al.
Epilepsy & behavior : E&B, 23(4), 497-499 (2012-03-24)
Because iatrogenic obesity may hinder medication compliance, it would be a reasonable approach to consider antiepileptic drugs (AEDs) that promote weight loss in overweight patients. We performed an open-label, observational study to assess the effects of zonisamide on weight in
Kouji Fukuyama et al.
Pharmaceuticals (Basel, Switzerland), 13(5) (2020-05-24)
To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN), mediodorsal thalamic nucleus (MDTN) to orbitofrontal cortex (OFC) associated with S286L-mutant α4β2-nicotinic
Vedat Ali Yürekli et al.
Cellular and molecular neurobiology, 33(2), 205-212 (2012-12-12)
Parkinson's disease is an incurable progressive neurological condition caused by a degeneration of dopamine-producing cells characterized by motor and non-motor symptoms. The major mechanisms of the antiepileptic actions of ZNS are inhibition of voltage-gated Na(+) channel, T-type voltage-sensitive Ca(2+) channel
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Related Content

Data Sheet - Z2001

Instructions

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