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Merck
CN

Z4876

Sigma-Aldrich

Anti-ZPR1 antibody, Mouse monoclonal

clone LG1, purified from hybridoma cell culture

Synonym(s):

Anti-Zinc Finger Protein 1

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About This Item

MDL number:
MFCD04118708
UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

LG1, monoclonal

form

buffered aqueous solution

mol wt

antigen ~51 kDa

species reactivity

mouse, yeast, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 20-30 μg/mL using total cell extracts of the A431 human epidermoid carcinoma cell line

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... ZNF259(8882)
mouse ... Zfp259(22687)

General description

ZPR1 is a zinc finger protein that interacts with eEF-1α to modulate cell proliferation. Upon mitogenic stiμLation, cytoplasmic ZPR1 moves to the nucleus and accuμLates in the nucleolus of dividing cells. ZPR1 deficiency causes decreased viability of cells and impaired nucleolar functions . Monoclonal Anti-ZPR1 antibody is specific for human, mouse, and yeast ZPR1.

Immunogen

full length human ZPR1.

Application

Monoclonal Anti-ZPR1 antibody is suitable for use in western blot (20-30 μg/mL using total cell extracts of the A431 human epidermoid carcinoma cell line). The product may also be used for immunocytochemistry, indirect ELISA and immunohistochemistry.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
116M4846V
014K4842

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Z Galcheva-Gargova et al.
Molecular biology of the cell, 9(10), 2963-2971 (1998-10-08)
The zinc finger protein ZPR1 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. The function of nuclear ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in the nucleolus of proliferating cells. The
L Gangwani et al.
The Journal of cell biology, 143(6), 1471-1484 (1998-12-16)
The zinc finger protein ZPR1 is present in the cytoplasm of quiescent mammalian cells and translocates to the nucleus upon treatment with mitogens, including epidermal growth factor (EGF). Homologues of ZPR1 were identified in yeast and mammals. These ZPR1 proteins

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