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Merck
CN

33014

Supelco

Chlorotrimethylsilane

pkg of 100 mL

Synonym(s):

TMCS, Derivatization Grade, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride

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About This Item

EC Number:
200-900-5
UNSPSC Code:
41116105

Key Documents

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grade

derivatization grade ((GC derivatization))
derivatization grade

description

Silylation reagent

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Silylations

packaging

pkg of 100 mL

technique(s)

GC/MS: suitable

General description

Chlorotrimethylsilane is widely used in characterising organolithium compounds. It is also used in establishing the degree of polymetallation by organolithium compounds.

Application

It was used to reconstitute the phytic acid residue during derivatization procedure, before injecting the residue into GC for determination of phytic acid content in biological samples. It was also used in toluene for silanizing all the glassware used for detecting, identifying and quantifying polychlorinated biphenyls (PCB) using solid-phase microextraction combined with gas chromatography with electron capture detection.

Other Notes

Reagent for trimethylsilyl chlorohydrin, trimethylsilyl and trimethylsilyl ether.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-18.4 °F - closed cup

Flash Point(C)

-28 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
LC25441V
LC15748V
LC09001V
LB99925
LB54957

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J G March et al.
Journal of chromatography. B, Biomedical sciences and applications, 757(2), 247-255 (2001-06-22)
A GC-MS method is reported for the determination of phytic acid based on purification by anion-exchange chromatography, enzymatic hydrolysis of phytic acid to myo-inositol and derivation to trimethylsilyl derivative, with scyllo-inositol as an internal standard. Analytical features of the method
M.G.Horning et al.
Journal of Gas Chromatography, 5, 297-297 (1967)
B. J. Wakefield
The Chemistry of Organolithium Compounds, 260-260 (2013)
D.R. Knapp
Handbook of Analytical Derivatization Reactions, 472-472 (1979)
Jszafranek et al.
Journal of Chromatography A, 88, 149-149 (1974)
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