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Merck
CN

33014

Chlorotrimethylsilane

pkg of 100 mL

Synonym(s):

TMCS, Derivatization Grade, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride

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About This Item

EC Number:
200-900-5
UNSPSC Code:
41116105

Key Documents

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grade

derivatization grade ((GC derivatization)), derivatization grade

description

Silylation reagent

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Silylations

packaging

pkg of 100 mL

technique(s)

GC/MS: suitable

General description

Chlorotrimethylsilane is widely used in characterising organolithium compounds. It is also used in establishing the degree of polymetallation by organolithium compounds.

Application

It was used to reconstitute the phytic acid residue during derivatization procedure, before injecting the residue into GC for determination of phytic acid content in biological samples. It was also used in toluene for silanizing all the glassware used for detecting, identifying and quantifying polychlorinated biphenyls (PCB) using solid-phase microextraction combined with gas chromatography with electron capture detection.

Other Notes

Reagent for trimethylsilyl chlorohydrin, trimethylsilyl and trimethylsilyl ether.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-18.4 °F - closed cup

flash_point_c

-28 °C - closed cup

ppe

Faceshields, Gloves, Goggles

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
LC25441V
LC15748V
LC09001V
LB99925
LB54957

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D.J.Harvey et al.
Journal of the Chemical Society. Perkin Transactions 1, 1, 1074-1074 (1972)
J F Kennedy et al.
Carbohydrate research, 57, 205-214 (1977-08-01)
The structures of the isomeric products obtained on trimethylsilylation of naturally occurring hexuronic acids and their sodium salts and lactones have been established by the application of n.m.r. (for anomeric configuration) and mass spectrometry (for ring size). The equilibria of
O. Ceder and B. Hansson
Acta Chemica Scandinavica, B30, 574-574 (1976)
M.B.Perry et al.
Journal of Chromatography A, 44, 614-614 (1969)
B. J. Wakefield
The Chemistry of Organolithium Compounds, 260-260 (2013)
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