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33045-U

Methoxyamine hydrochloride

bottle of 5 g

Synonym(s):

O-Methoxyamine HCl, O-Methylhydroxylamine hydrochloride, Methoxylamine hydrochloride

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About This Item

Linear Formula:
CH3ONH2 · HCl
CAS Number:
593-56-6
Molecular Weight:
83.52
EC Number:
209-798-7
UNSPSC Code:
12352200
PubChem Substance ID:
329754446
Beilstein/REAXYS Number:
3589723
MDL number:
MFCD00012951
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description

Alkylation reagent

packaging

bottle of 5 g

mp

151-154 °C (lit.)

SMILES string

Cl.CON

InChI

1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H

InChI key

XNXVOSBNFZWHBV-UHFFFAOYSA-N

General description

Methoxyamine hydrochloride (MX) is a derivatizing agent. It traps aldehyde groups forming stable intermediates. It plays a role as an inhibitor of base excision repair, rapidly and covalently binds to apurinic/apyrimidinic sites. MX is a commonly used reagent for the generation of oxime derivatives of aldehyde- or ketone-group containing compounds.

Application

MX was used as derivatizing agent during sample preparation, in a comparative study evaluating online coupling of gas chromatography (GC)-mass spectrometry (MS) and flame ionization detector (FID) as ways of cross-detector analysis.
Methoxyamine hydrochloride may be used as an oximation reagent prior to the silylation derivatization of the metabolites of:
  • Mouse plasma samples preceding their quantification by GC combined with quadrupole mass spectrometry (Q/MS) as well as time-of-flight (TOF) MS.
  • Arabidopsis thaliana leaves preceding their determination by gas chromatography-mass spectrometry (GC-MS).
  • Corynebacterium glutamicum samples preceding their analysis by GC-MS.
  • L-β-Methylamino-alanine (BMMA) in human tissue samples preceding their determination by GC-TOF MS.

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
LB58376
LB55306
LB51543
LB49757
LB44598

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