Skip to Content
Merck
CN

33358-U

trimethylanilinium hydroxide (TMAH)

0.2 M in methanol

Synonym(s):

Trimethylphenylammonium hydroxide solution, Phenyltrimethylammonium hydroxide, TMAH

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
(CH3)3N(OH)C6H5
CAS Number:
1899-02-1
Molecular Weight:
153.22
PubChem Substance ID:
329754492
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
3917033
MDL number:
MFCD00041899

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

[OH-].C[N+](C)(C)c1ccccc1

InChI key

HADKRTWCOYPCPH-UHFFFAOYSA-M

InChI

1S/C9H14N.H2O/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H2/q+1;/p-1

grade

derivatization grade ((GC derivatization))

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

packaging

pkg of 10 × 1 mL

concentration

0.2 M in methanol

General description

Trimethylanilinium hydroxide (TMAH) is an alkylating agent used effectively during esterification of carboxylic acids, etherfication of alcohols and N-alkylation of amino groups. This reagent forms N-methyl derivatives of molecules replacing hydrogen atoms attached to nitrogen.

Application

It is used to derivatize the serum sample for determination of Topiramate in Epileptic patients using GC-MS analysis.

Other Notes

Reagent for carboxylic acid methyl ester, methyl esters.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Faceshields, Gloves, Goggles

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LC23215V
LC19463V
LC18600V
LC17935V
LC17684V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E.W. Robb and J.J. Westbrook III
Analytical Chemistry, 35, 1644-1644 (1963)
Vladimir Zaikin, John M. Halket
A Handbook of Derivatives for Mass Spectrometry, 218-219 (2009)
A capillary GC method using nitrogen phosphorus detection for determination of topiramate in patients with epilepsy.
Malakova, J., et al.
Chromatographia, 66, 363-367 (2007)
Timothy J Jensen et al.
Journal of photochemistry and photobiology. B, Biology, 100(2), 100-111 (2010-06-19)
Five cationic porphyrins bearing one to four -N(CH(3))(3)(+) groups linked to the p-phenyl positions of 5,10,15,20-tetraphenylporphyrin (TPP) were synthesized in order to study the effect of overall charge and its distribution on the cellular uptake, phototoxicity and intracellular localization using
A Ranz et al.
Journal of biochemical and biophysical methods, 69(1-2), 3-14 (2006-03-28)
In the present study, a derivatization method for the determination of acidic herbicides has been investigated. This procedure involves the methylation with the quaternary ammonium salt trimethylanilinium hydroxide (TMAH) directly in the gas chromatographic auto-sampler vial for analysis by gas
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service