33358-U
trimethylanilinium hydroxide (TMAH)
0.2 M in methanol
Synonym(s):
Trimethylphenylammonium hydroxide solution, Phenyltrimethylammonium hydroxide, TMAH
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About This Item
Linear Formula:
(CH3)3N(OH)C6H5
CAS Number:
Molecular Weight:
153.22
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
3917033
MDL number:
grade
derivatization grade ((GC derivatization))
reaction suitability
reagent type: derivatization reagent
reaction type: Esterifications
packaging
pkg of 10 × 1 mL
concentration
0.2 M in methanol
SMILES string
[OH-].C[N+](C)(C)c1ccccc1
InChI
1S/C9H14N.H2O/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H2/q+1;/p-1
InChI key
HADKRTWCOYPCPH-UHFFFAOYSA-M
General description
Trimethylanilinium hydroxide (TMAH) is an alkylating agent used effectively during esterification of carboxylic acids, etherfication of alcohols and N-alkylation of amino groups. This reagent forms N-methyl derivatives of molecules replacing hydrogen atoms attached to nitrogen.
Application
It is used to derivatize the serum sample for determination of Topiramate in Epileptic patients using GC-MS analysis.
Other Notes
Reagent for carboxylic acid methyl ester, methyl esters.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1
target_organs
Eyes
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
ppe
Faceshields, Gloves, Goggles
Regulatory Information
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E.W. Robb and J.J. Westbrook III
Analytical Chemistry, 35, 1644-1644 (1963)
A capillary GC method using nitrogen phosphorus detection for determination of topiramate in patients with epilepsy.
Malakova, J., et al.
Chromatographia, 66, 363-367 (2007)
Vladimir Zaikin, John M. Halket
A Handbook of Derivatives for Mass Spectrometry, 218-219 (2009)