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Merck
CN

48520-U

Chloroform

analytical standard

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
UNSPSC Code:
77101502
NACRES:
NA.24
PubChem Substance ID:
329757381
EC Number:
200-663-8
Beilstein/REAXYS Number:
1731042
MDL number:
MFCD00000826

Key Documents

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InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

InChI

1S/CHCl3/c2-1(3)4/h1H

SMILES string

ClC(Cl)Cl

grade

analytical standard

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.8%

CofA

current certificate can be downloaded

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

colorless

mp

−63 °C (lit.)

application(s)

agriculture
environmental

format

neat

storage temp.

2-30°C

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General description

Chloroform is widely used as an industrial solvent, aerosol propellant and as a preservative in concentrations between 0.1 and 0.5 percent in aqueous pharmaceutical preparations. It is a human carcinogen with cardiotoxic and hepatotoxic effects and is also known to cause skin infections.

Application

Chloroform may be used as an analytical standard for the determination of the analyte in aqueous pharmaceutical formulations by chromatography and drinking water samples by spectrofluorimetry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

ppe

Eyeshields, Faceshields, Gloves

Regulatory Information

危险化学品
易制毒化学品（2类）
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Certificates of Analysis (COA)

Lot/Batch Number
LC23888V
LC16449V
LC11350V
LC03142V
LB83513V

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A sensitive colorimetric method for determination of chloroform
Pillai AK, et al.
Indian Journal of Chemical Technology, 6, 294-296 (1999)
Fluorimetric determination of chloroform in drinking water
Okumura K, et al.
Analyst, 107(1281), 1498-1502 (1982)
The determination of chloroform in aqueous pharmaceutical preparations
Brealey L, et al.
Analyst, 84(997), 221-225 (1959)
Radovan Spurny et al.
The Journal of biological chemistry, 288(12), 8355-8364 (2013-02-01)
Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-aminobutyric acid GABA(A/C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics, including general anesthetics. Here, we
Pramod Kumar et al.
Tissue engineering. Part C, Methods, 21(7), 660-670 (2014-12-24)
Tissue engineering by self-assembly uses the cells' secretome as a regeneration template and biological factory of trophic factors. Despite the several advantages that have been witnessed in preclinical and clinical settings, the major obstacle for wide acceptance of this technology
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