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Merck
CN

48554

N-Nitrosodi-n-propylamine

analytical standard

Synonym(s):

NDPA

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About This Item

Empirical Formula (Hill Notation):
C6H14N2O
CAS Number:
Molecular Weight:
130.19
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
210-698-0
MDL number:
NACRES:
NA.24
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InChI key

YLKFDHTUAUWZPQ-UHFFFAOYSA-N

InChI

1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3

SMILES string

CCCN(CCC)N=O

grade

analytical standard

CofA

current certificate can be downloaded

packaging

ampule of 100 mg

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

2-30°C

Quality Level

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General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodi-n-propylamine solution is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitrosodi-n-propylamine may be used as an analytical reference standard for the determination of volatile nitrosamines in meat samples using gas chromatography coupled with flame ionization detector (GC-FID) technique.

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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A new method for quantifying N-nitrosamines in wastewater samples by gas chromatography?triple quadrupole mass spectrometry.
Yoon S, et al.
Talanta, 97, 256-261 (2012)
Development and validation of GC-FID method for the determination of volatile N-nitrosamines in meat
Al-Kaseem M, et al.
International Journal of Pharmaceutical Sciences Review and Research, 25, 59-64 (2014)
T Suzuki et al.
Mutation research, 444(2), 259-268 (1999-10-16)
We studied five carcinogens for (a) organ-specific mutagenicity and expression time in the transgenic (TG) mouse mutation assay and (b) clastogenicity in the peripheral blood micronucleus assay in the same mice. Groups of mice were injected intraperitoneally (ip) with N-nitroso-di-n-propylamine
M A Moore et al.
Journal of the National Cancer Institute, 78(2), 289-293 (1987-02-01)
The effects of butylated hydroxyanisole [(BHA) CAS: 25013-16-5], alpha-tocopherol [(TC) CAS: 59-02-9], and carbazole [(CA) CAS: 86-74-8] administered subsequent to a single dose of 2,2'-dioxo-N-nitrosodipropylamine [(DOPN) CAS: 60599-38-4] on the development of putative preneoplastic lesions were investigated in Syrian golden
D S Longnecker
Environmental health perspectives, 56, 245-251 (1984-06-01)
Focal proliferative changes in the acinar cells of the pancreas of rats have been induced by several systemically administered carcinogens including azaserine, N-nitrosobis(2-oxopropyl)amine, N-nitroso-(2-hydroxypropyl) (2-oxopropyl)amine, and N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO). Foci, nodules, and adenomas induced by these carcinogens are usually made

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