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Merck
CN

54801-U

Sigma-Aldrich

Superdex® Gel Filtration Column

phase Superdex 200 HR10/300 GL, L × I.D. 30 cm × 10 mm, 13-15 μm particle size

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About This Item

UNSPSC Code:
13111000
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L × I.D.

30 cm × 10 mm

matrix active group

Superdex 200 HR10/300 GL phase

particle size

13-15 μm

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General description

Superdex Peptide offers very high resolution when compared to other size exclusion chromatography medium in the molecular weight range of 100-7,000 Daltons, making it the column of choice for separating peptides. Superdex 75 is ideal for separating monomers and dimers of low molecular weight recombinant proteins and peptides. Superdex 200 is intended for analyses of larger proteins (e.g., monoclonal antibodies).

Superdex 75 HR10/300 GL and Superdex 200 HR10/300 GL are high-resolution gel filtration columns for high-performance analytical and semi-preparative applications involving μg to mg of sample. These columns also can be used in conventional HPLC and FPLC systems. HiLoad columns are laboratory-scale columns of preparative grade Superdex 75 and Superdex 200 media. They can be used with a wide variety of equipment, including single pump-based configurations and FPLC, HPLC, and pilot ­scale systems.
Superdex prepacked columns are designed for high-performance, laboratory-scale separations of proteins, peptides, and other biomolecules according to size. High performance gel filtration offers fast separations with high resolution for a variety of applications including protein purification, studies of complex formation, and screening of uncharacterized samples.
Superdex 75 5/150 GL and Superdex 200 5/150 GL have small bed volumes, which is useful for a range of applications such as screening solubilization conditions for membrane proteins, the study of protein-protein interactions, and rapid purity check of proteins. These columns are an excellent choice when time and sample/buffer consumption is more important than the highest resolution since less buffer and sample volumes are required.

Application

Superdex prepacked columns are designed for high-performance, laboratory-scale separations of proteins, peptides, and other biomolecules according to size. Various applications include protein purification, studies of complex formation, and screening of uncharacterized samples.

Features and Benefits

  • High resolution over a wide range of molecular weight (100 to 600,000 Daltons)
  • Rapid separations
  • High physical and chemical stability
  • Long column life
  • Column design compatible with biological analytes
  • Easy scale-up (HR columns to HiLoad columns)
  • Pre-packed for convenience and reproducibility

Legal Information

FPLC is a trademark of Cytiva
Superdex is a registered trademark of Cytiva

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Colistin A and colistin B among inhibitory substances of Paenibacillus polymyxa JB05-01-1
Naghmouchi, K., et al.
Archives of Microbiology (2011)
Maya Haj Hassan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(27), 2935-2940 (2011-09-16)
Isolation of phosphatidyl-ethanolamine-binding protein-1 (PEBP-1) from bovine brain was described almost three decades ago but it required a large number of steps to reach high purity. After the fractionation of bovine testis proteins by ammonium sulfate precipitation we found that
Yong Ding et al.
Journal of chromatography. A, 1218(47), 8503-8510 (2011-10-26)
Refolding enables bioprocesses predicated on proteins expressed as inclusion bodies in Escherichia coli. Optimization of size-exclusion chromatography (SEC) refolding is a significant challenge because a wide range of factors, including the choice of gel media, the column dimensions and configuration

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