G005174
SFC Analysis of Warfarin Enantiomers on Astec® Cellulose DMP, Methanol Gradient
application for SFC
test parameters
column: Astec Cellulose DMP, 15 cm x 4.6 mm I.D., 5 μm particles (51098AST)
mobile phase: [A] carbon dioxide; [B] methanol;
Gradient of 5-65% methanol in 3 min., hold for 1 min
flow rate: 4 mL/min
pressure: 1450 psi (100 bar)
column temp.: 35 °C
detector: UV, 220 nm
injection: 5 μL
sample: warfarin
suitability
application for SFC
application(s)
clinical
pharmaceutical (small molecule)
Analysis Note
SFC data provided by Dr. Christina Kraml, Lotus Separations, LLC, Princeton, NJ.
Instrument: Berger Analytical SFC system equipped with a dual pump (FCM-1200), autosampler (ALS 3100), column oven (TCM-200) and diode-array detector (DAD-4100); from Mettler Toledo.
Instrument: Berger Analytical SFC system equipped with a dual pump (FCM-1200), autosampler (ALS 3100), column oven (TCM-200) and diode-array detector (DAD-4100); from Mettler Toledo.
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
Analyte
Description
Warfarin
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