G006149
UHPLC/MS Analysis of Various Drug Substances on Titan C18
application for HPLC
technique(s)
HPLC: suitable
test parameters
column: Titan C18, 5 cm x 2.1 mm I.D., 1.9 μm particles (577122-U)
mobile phase: [A] 5 mM ammonium formate; [B] 5 mM ammonium formate in 90:10 (v:v) acetonitrile:water
gradient: 30 to 70% B in 3.0 min
flow rate: 0.3 mL/min
column temp.: 35 °C
detector: MS/MS
injection: 3 μL
sample: 50 ng/mL in methanol
suitability
application for HPLC
application(s)
forensics and toxicology
pharmaceutical (small molecule)
Analysis Note
A Titan C18 column provided rapid, baseline resolution of this set of drug substances. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.
Legal Information
Analyte
Description
Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Propranolol hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Carbamazepine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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