MET677A
Leptophos oxon
analytical standard
InChI
1S/C13H10BrCl2O3P/c1-18-20(17,9-5-3-2-4-6-9)19-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3
InChI key
MAKUYRKZFGSMMG-UHFFFAOYSA-N
grade
analytical standard
packaging
ampule of 50 mg
manufacturer/tradename
Chem Service, Inc. MET-677A
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
agriculture
environmental
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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S A Soliman et al.
Journal of analytical toxicology, 5(4), 183-186 (1981-07-01)
Hen brain microsomal preparation has phenyl valerate-hydrolyzing activity associated with neurotoxic esterase activity. Part of that activity is due to paraoxon-insensitive esterases and a sub-part of this is sensitive to neurotoxic organophosphates, i.e., mipafox and leptophosoxon. This neurotoxic agent sensitive
S H Preissig et al.
Environmental research, 17(2), 242-250 (1978-10-01)
Recent investigation into a possible association between exposure to Leptophos and neurological symptoms in insecticide factory workers makes study of the neurological effects of Leptophos in the experimental situation particularly important. The present study utilizes a single oral dose of
J H Reinders et al.
Toxicology letters, 17(1-2), 107-111 (1983-06-01)
In comparing neurotoxic esterase (NTE) inhibition properties of a series of phenylphosphonates, it was discovered that certain compounds including leptophos inhibited mipafox-insensitive phenylvalerate hydrolases. This leads to erroneous values for NTE inhibition which can be corrected by a differential assay:
A H El-Sebae et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 16(4), 465-474 (1981-01-01)
Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. TOCP was included as a reference. Cyanofenphos blocked the catecholamine B-receptor binding activity with 3H-norepinephrine at
M H Fulton et al.
Toxicology letters, 26(2-3), 175-180 (1985-08-01)
The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of
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