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About This Item
Linear Formula:
HSCH2CH(NHCOCH3)CO2H
CAS Number:
Molecular Weight:
163.19
Beilstein:
1724426
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
acetylcysteine
manufacturer/tradename
USP
mp
106-108 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI key
PWKSKIMOESPYIA-BYPYZUCNSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Acetylcysteine USP reference standard intended for use in specified compendial tests and assays.
Also used to prepare standard stock and standard solution for assay by using the liquid chromatography method in conjunction with uv detector according to the given below monographs of United States Pharmacopeia (USP):
Also used to prepare standard stock and standard solution for assay by using the liquid chromatography method in conjunction with uv detector according to the given below monographs of United States Pharmacopeia (USP):
- Acetylcysteine Solution
- Acetylcysteine
- Acetylcysteine Compounded Solution
Biochem/physiol Actions
Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Acetylcysteine Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 27(3), 82-82 (2020)
Acetylcysteine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 31(3), 82-82 (2020)
Acetylcysteine Compounded Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(2), 83-83 (2020)
Michael Berk et al.
Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of
Eduesley Santana-Santos et al.
The Annals of thoracic surgery, 97(5), 1617-1623 (2014-03-25)
The renoprotective effect of N-acetylcystein in patients undergoing coronary artery bypass graft surgery is controversial. We assessed the renoprotective effect of the highest dose of N-acetylcystein sanctioned for clinical use in a prospective, double-blind, placebo-controlled study including 70 chronic kidney
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